Dynamic Generalized Gromov-Wasserstein Optimal Transport extends classical optimal transport by incorporating structure-aware transport costs, which is especially relevant for spatial transcriptomics where preserving tissue structure is crucial. The paper introduces TP-DATE, a simulation-free framework that generalizes GW-OT dynamically, formulating static and dynamic Quadratic-form OT through path actions and proving their equivalence. TP-DATE employs travelling-pair flow matching to enable interacting conditional paths, resulting in better preservation of spatial structure and improved continuous 3D dynamics reconstruction on both synthetic and real spatial transcriptomics data.
arXiv:2608. 15306v1 Announce Type: cross Abstract: High-throughput single-cell and spatial transcriptomic technologies provide high-resolution snapshots of heterogeneous cellular states, but their destructive nature prevents repeated measurements of the same cells over time.
By Mary Chriselda Antony Oliver, Kaitlyn Hohmeier, Tuyen Tran, Alejandra Castillo, Caroline Moosm\"uller, Shiying Li
arXiv:2510. 01894v3 Announce Type: replace Abstract: Many natural dynamic processes -- such as in vivo cellular differentiation or disease progression -- can only be observed through the lens of static sample snapshots.
By Thomas Gravier, Thomas Boyer, Auguste Genovesio
arXiv:2608.21070v1 Announce Type: cross
Abstract: Inferring continuous system evolution from sparse temporal snapshots is a key challenge in generative modeling and single-cell omics. While Optimal T...
By Yuhao Sun, Zekun Wu, Zixun Huang, Peijie Zhou
arXiv:2607. 04738v1 Announce Type: cross Abstract: Reconstructing population dynamics is a central problem in the physical and data sciences.
By Markus Heinonen, Yair Shenfeld, Ricardo Baptista, Daniel Waxman, Dmitry Batenkov, Tim Cooijmans, Eli Bingham
Reconstructing population dynamics is a central problem in the physical and data sciences. Often, the dynamics are modeled as a Wasserstein gradient flow (WGF): a curve of distributions driven by an energy functional.
The paper introduces SUDO, a simulation‑free framework for unbalanced dynamic optimal transport (UDOT) that supports general convex growth penalties beyond the quadratic Wasserstein‑Fisher‑Rao case. By showing that concave penalties lead to degenerate solutions, the authors focus on convex penalties, learning conditional paths and transport costs to solve a semi‑coupling problem and then applying unbalanced flow matching. On benchmark datasets, SUDO matches the accuracy of analytical WFR solvers while being faster than simulation‑based methods, and it also handles asymmetric penalties that better reflect proliferation‑dominant biological priors.
By Junda Ying, Yuxuan Wang, Bowen Yang, Peijie Zhou, Lei Zhang
arXiv:2609.25659v1 Announce Type: new
Abstract: Many scientific datasets, such as molecular conformational ensembles or single-cell tissue measurements, are naturally modeled as meta-distributions: d...
By Doron Haviv, Edward De Brouwer, Rishabh Anand, Rex Ying, A\"icha Bentaieb, Gabriele Scalia, Hector Corrada Bravo
arXiv:2608. 04234v1 Announce Type: cross Abstract: We study the problem of aligning data from multiple modalities into a shared representation space, focusing on settings where strong pretrained unimodal encoders are available but cross-modal paired data are scarce.
By Yixuan Florence Wu, Yilun Zhu, Naichen Shi
We introduce Potential Matching Optimal Transport (PMOT), a potential-flow framework for general $p$-cost optimal transport with $c_p(x,y)=\|x-y\|^p$. PMOT parameterizes the CNF velocity field with a scalar potential in the generalized Benamou--Brenier form for the chosen exponent $p$.
arXiv:2607. 06583v1 Announce Type: cross Abstract: DNA methylation (DNAm) serves as one of the most robust molecular biomarkers of biological aging.
By Chandan Gupta, Syed Haider, Pietro Li\`o
arXiv:2606. 05327v1 Announce Type: new Abstract: Flow matching (FM) has emerged as a powerful framework for learning dynamic transport maps between two empirical distributions.
By Raghav Kansal, David Crair, Nghia Nguyen, Scott Pope, Bradley Parry