arXiv:2506. 11152v4 Announce Type: replace-cross Abstract: Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell level.
By Hiren Madhu, Jo\~ao Felipe Rocha, Tinglin Huang, Siddharth Viswanath, Smita Krishnaswamy, Rex Ying
arXiv:2603. 13432v4 Announce Type: replace-cross Abstract: Spatial Transcriptomics (ST) profiles thousands of gene expression values at discrete spots with precise coordinates on tissue sections, preserving spatial context essential for clinical and pathological studies.
By Yishun Zhu, Jiaxin Qi, Jian Wang, Yuhua Zheng, Jianqiang Huang
arXiv:2608. 14924v1 Announce Type: cross Abstract: Spatial transcriptomics (ST) links tissue morphology with molecular programs, motivating multimodal pretraining methods that align histology images with gene expression.
By Azim Dehghani Amirabad, Junchao Zhu, Pushpak Pati, Walid Abdelmoula, Tommaso Mansi, Rui Liao
arXiv:2607. 09166v1 Announce Type: new Abstract: Spatial transcriptomics enables profiling of spatial gene expression but is limited by high cost and low throughput, motivating prediction from H&E histopathology images.
By Keunho Byeon, Sunhong Park, Jeewoo Lim, Jin Tae Kwak
arXiv:2608. 06659v1 Announce Type: new Abstract: This paper shows that latent-space predictive pretraining can provide a scalable route to foundation models for spatial transcriptomics.
By Haiping Liu, Qian Zhao, Lijing Lin, Jingyuan Sun, Hongpeng Zhou
arXiv:2608. 14710v1 Announce Type: cross Abstract: Predicting spatial gene expression from hematoxylin and eosin (H\&E)-stained images offers a cost-effective alternative to spatial transcriptomics (ST).
By Ruochen Liu, Wei Lou
arXiv:2606. 03644v1 Announce Type: new Abstract: Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times.
By Fengtao Zhou, Yingxue Xu, Zhengyu Zhang, Yihui Wang, Zhengrui Guo, Ling Liang, Jiabo Ma, Cheng Jin, Ziyi Liu, Huajun Zhou, Hongyi Wang, Du Cai, Chenglong Zhao, Xi Wang, Can Yang, Yu Wang, Wenbin Li, Feng Gao, Zhe Wang, Zhenhui Li, Xiuming Zhang, Li Liang, Hao Chen
arXiv:2607. 14410v1 Announce Type: new Abstract: Spatially resolved omics studies increasingly combine transcriptomic and epigenomic assays, yet downstream analysis is often still performed using single-modality pipelines.
By Jagan Mohan Reddy Dwarampudi, Veena Kochat, Suresh Satpati, Kunal Rai, Tania Banerjee
arXiv:2507. 04704v3 Announce Type: replace-cross Abstract: Understanding how cellular morphology, gene expression, and spatial context jointly shape tissue function is a central challenge in biology.
By Zhenglun Kong, Mufan Qiu, John Boesen, Xiang Lin, Sukwon Yun, Tianlong Chen, Manolis Kellis, Marinka Zitnik
arXiv:2608. 14330v1 Announce Type: new Abstract: Spatial transcriptomics (ST) enables genome-wide gene expression profiling while preserving tissue architecture, but its cost and limited scalability remain major bottlenecks.
By Ruyter Swann, Dorent Reuben, Racoceanu Daniel
arXiv:2606. 31394v1 Announce Type: cross Abstract: Artificial intelligence is transforming our capability to solve biological challenges.
By Jisung Park, Seohyeon Kang, Daeun Yoo, Eunsu Lee, Seoin Cho, Wooyeop Choi, Ian Choi, James R. Evan, Daesoo Kim, Sonia Gandhi, Minee L. Choi
arXiv:2608. 14355v1 Announce Type: new Abstract: Spatial transcriptomics (ST) enables the simultaneous profiling of gene expression and tissue morphology, creating an opportunity to learn multimodal representations capturing shared morpho-transcriptomic structure.
By Julian Ostermaier, Swann Ruyter, Reuben Dorent, Daniel Racoceanu