Mammalian cell-culture processes underpin the manufacture of many biopharmaceuticals, yet keeping a run on track is hard: critical process parameters drift over days, and an off-specification trend is often confirmed too late to intervene. Early-stage, multi-day forecasts could enable timely adjustment of feeding, sampling, and control, but bioprocess forecasting is challenging because measurements are sparse and irregularly sampled, operating conditions are heterogeneous across cell lines and media, and runs with near-identical early behaviour can diverge into different futures.
arXiv:2606. 26520v1 Announce Type: cross Abstract: Mammalian cell-culture processes underpin the manufacture of many biopharmaceuticals, yet keeping a run on track is hard: critical process parameters drift over days, and an off-specification trend is often confirmed too late to intervene.
arXiv:2608. 06107v1 Announce Type: new Abstract: Machine learning offers a promising avenue to accelerate physical simulations by replacing computationally expensive traditional Partial Differential Equation (PDE) solvers with fast, differentiable surrogate models.
arXiv:2601. 13534v3 Announce Type: replace-cross Abstract: Time series generation (TSG) is widely used across domains, yet most existing methods assume regular sampling and fixed output resolutions.
The paper investigates why latent neural surrogate solvers, which compress physical system dynamics into a lower‑dimensional space, often fail during long‑horizon autoregressive rollouts. It demonstrates that training the latent representation only for reconstruction leads to instability, and proposes a set of training interventions—Koopman operator learning, Hamming noise injection, and multi‑step rollout fine‑tuning—that align the latent space with long‑horizon forecasting. These interventions reduce long‑rollout error by about 40 % and achieve accuracy comparable to full‑resolution models while using far fewer floating‑point operations and GPU memory, enabling stable extrapolation in mesoscale crystal‑plasticity simulations of high‑cycle fatigue.
arXiv:2610.00405v1 Announce Type: cross Abstract: Time-series foundation models (TSFMs) perform strongly across forecasting tasks, but their per-series inference is ill-suited to neighbor-rich foreca...
arXiv:2606. 05264v1 Announce Type: new Abstract: Training robust multivariate time series forecasting models requires large, diverse corpora, yet many real-world domains provide only a handful of observed sequences.
arXiv:2605. 05540v2 Announce Type: replace Abstract: Fast surrogate modeling for high-dimensional physical dynamics requires more than low short-term error: useful models must roll out efficiently while preserving the statistical structure of long trajectories.
The paper introduces Chameleon, a channel‑dependent state space model for multivariate time series forecasting that allows data‑dependent, fine‑grained interactions across variables while maintaining linear scaling with the number of variables. By integrating selective state space models with a Kalman filter and adapting GatedDeltaNet as the backbone, Chameleon improves generalization and achieves lower MSE and MAE on strongly dependent ODE and PEMS datasets compared to both channel‑independent and prior channel‑dependent methods. Across 28 benchmark settings, it outperforms baselines in the majority of cases and demonstrates competitive training‑time and memory efficiency on Traffic and ETT datasets.
arXiv:2608. 14744v1 Announce Type: new Abstract: Recovering high-resolution states from sparse, low-resolution observations is a central challenge in scientific machine learning and data assimilation.
arXiv:2607. 20539v1 Announce Type: cross Abstract: While deep learning has accelerated drug discovery, its impact on biomanufacturing has been considerably more limited.
arXiv:2602. 08733v2 Announce Type: replace Abstract: Ordinary differential equations (ODEs) are central to scientific modelling, but inferring their vector fields from noisy trajectories remains challenging.
RD‑JEPA is a joint‑embedding predictive architecture designed for self‑supervised pretraining on reaction‑diffusion trajectories. The model is pretrained on five parameterized systems and then adapted to three held‑out systems that were not seen during pretraining. Using as few as one, five, or ten complete trajectories from a held‑out system, RD‑JEPA outperforms five supervised surrogate baselines, an independently trained control that removes the trajectory‑dependent predictive latent pathway, and an architecture‑matched model trained from scratch, achieving lower mean relative discrete β field error and mean absolute spatial first‑difference error across various output resolutions, forecast horizons, and adaptation trajectory choices.