arXiv Machine Learning

In Silico Study for Optimizing Intensity and Focality Electrode Configurations for Directional DBS Under Uncertainty Using Metaheuristic L1L1 Method

arXiv:2506. 13452v3 Announce Type: replace-cross Abstract: Background and Objective: As Deep Brain Stimulation (DBS) advances toward directional leads and optimization-based current steering, selecting electrode contact configurations becomes complex.

arXiv AI
Sep 24

AI-Driven Neural Surrogates for In Silico Design of Cognitive-Affective Neuromodulation Targets

arXiv:2609.27729v1 Announce Type: cross Abstract: In neuropsychiatry, the primary goal is often not only to decode brain activity but to change it, for example to lessen a negative affective bias or...

By Marco Rothermel, Madleen Stenger, Soroush Daftarian, Svenja Jule Francke, Bita Shariatpanahi, Jos\'e C. Garc\'ia Alanis, Mohammad-Ali Nikouei Mahani, Stefan G. Hofmann, Tim Hahn, Hamidreza Jamalabadi
arXiv AI
Jul 8

Reduced NEXI protocol for the quantification of human gray matter microstructure on the Connectome 2.0 scanner

arXiv:2509. 09513v3 Announce Type: replace-cross Abstract: Biophysical diffusion MRI models like Neurite Exchange Imaging (NEXI) are essential for probing gray matter microstructure, estimating compartment diffusivities, neurite fraction, and exchange time.

By Quentin Uhl, Tommaso Pavan, Julianna Gerold, Kwok-Shing Chan, Yohan Jun, Shohei Fujita, Aneri Bhatt, Yixin Ma, Qiaochu Wang, Hong-Hsi Lee, Susie Y. Huang, Berkin Bilgic, Ileana Jelescu
arXiv Machine Learning
Aug 20

A FEM-Based Surrogate Modelling and Optimization Framework for Physics-Constrained Electromagnetic Coil Design

The paper presents a surrogate‑assisted optimization framework for designing a seven‑parameter current‑excited electromagnetic coil, coupling a 2‑D axisymmetric FEM model with a Matern 5/2 Gaussian‑process surrogate. Sequential Bayesian optimization using expected improvement (EI) is compared with COBYLA and BOBYQA, showing that the ranking of methods depends on the FEM evaluation budget and that different methods excel at early progress, terminal response, or computational cost. A retrospective study indicates no clear advantage of EI over posterior‑mean ranking on this smooth response surface, and the results are specific to the axisymmetric benchmark used.

By Yucheng Liu
arXiv Machine Learning
Jun 3

Correcting Neural Operator Spectral Bias via Diffusion Posterior Sampling with Sparse Observations

arXiv:2606. 03936v1 Announce Type: new Abstract: Neural operator surrogates (NO) approximate PDE solutions orders of magnitude faster than numerical solvers, but suffer from spectral bias: high-frequency content is systematically attenuated, limiting reliability where fine-scale structure matters.

By Niccol\`o Perrone, Fanny Lehmann, Stefania Fresca, Filippo Gatti
arXiv Statistics ML
Sep 28

Bayesian Uncertainty Quantification for fMRI Functional Connectivity via Simulation-Based Inference

The paper introduces a Bayesian framework that models BOLD dynamics as coupled Ornstein‑Uhlenbeck processes and uses Sequential Neural Posterior Estimation to produce connectivity posteriors while accounting for measurement noise. Applied to 28 healthy controls scanned at 7T, the method quantifies uncertainty from scanner noise, subject variability, and scan length, revealing that about 46 voxels per ROI and 7 minutes of 7T data suffice for 90% of asymptotic precision. It also shows that 7T achieves within‑session precision 40% faster than 3T and requires roughly 37 times less per‑subject scan time to reach population‑level convergence, offering concrete, scanner‑specific guidance for protocol optimization.

By Simon Carter, Zeming Kuang, Lilianne R. Mujica-Parodi, Helmut H. Strey
Hugging Face Trending Papers
Jun 1

Realistic noise synthesis reduces bias and improves tissue microstructure estimation with supervised machine learning

Diffusion MRI enables non-invasive probing of tissue microstructure, but accurate parameter estimation is challenged by noise-related effects. In supervised machine learning frameworks trained on simulated data, discrepancies between the noise characteristics of simulated and acquired signals introduce a form of covariate shift, whereby the input signal distribution differs between training and inference.

arXiv Machine Learning
Aug 28

Robust Neural Stimulation Response Modeling Through Meta-Learning and Pretraining

The study introduces a meta-learning and pretraining approach to improve neural stimulation response modeling. By extending temporal basis function models with a MAML-based architecture, the authors demonstrate a significant reduction in catastrophic forecast failures and narrower prediction intervals across 40 optogenetic stimulation sessions in non-human primates. The method also cuts calibration requirements by 50–90%, making closed‑loop stimulation more feasible within clinical time constraints.

By Matthew J Bryan, Daniel C Muir, Felix Schwock, Azadeh Yazdan-Shahmorad, Rajesh P N Rao
Hugging Face Trending Papers
Jun 2

Correcting Neural Operator Spectral Bias via Diffusion Posterior Sampling with Sparse Observations

Neural operator surrogates (NO) approximate PDE solutions orders of magnitude faster than numerical solvers, but suffer from spectral bias: high-frequency content is systematically attenuated, limiting reliability where fine-scale structure matters. Sparse sensor measurements of the field are often available too, offering pointwise accuracy without spectral distortion but covering only a small fraction of the domain.

arXiv Machine Learning
Jun 18

A Human-in-the-Loop Bayesian Optimization Framework for Constraint-Aware Bioprocess Development

arXiv:2606. 19230v1 Announce Type: new Abstract: This work presents an extension to Pareto Front Guided Sampling (PFGS), a Human-in-the-Loop (HitL) Bayesian Optimization (BO) framework in which Gaussian process (GP) surrogate-derived quantities are reformulated as objectives of a multi-objective optimization problem, and the resulting Pareto front is exposed to a domain expert for interactive candidate selection rather than returning a single automated recommendation.

By Samuel Stricker, Claus Wirnsperger, Alessandro Butt\'e, Laura Helleckes, Gonzalo Guill\'en Gos\'albez, Antonio del Rio Chanona, Mehmet Mercang\"oz