The paper investigates using Large Language Models (LLMs) as post-hoc auditors for symbolic regression models produced by genetic programming. By having three LLMs analyze and rank four evolved expressions across multiple runs, the study compares the LLM-generated rankings and interpretations with assessments from three clinicians. Results show that LLMs provide more favorable comparative rankings than isolated term-level interpretations, yet they also generate physiologically and mathematically questionable explanations, suggesting they are best used under expert oversight rather than for autonomous validation.
arXiv:2606. 28381v1 Announce Type: cross Abstract: Symbolic regression via genetic programming routinely fails on small, wide datasets - a regime common in clinical-trial monitoring, biostatistics, and engineering pilot studies - by converging on bloated, overfit expressions that exploit correlation rather than prediction.
arXiv:2511. 04124v3 Announce Type: replace Abstract: Symbolic regression (SR) models complex systems by discovering mathematical expressions that capture underlying relationships in observed data.
arXiv:2606. 07704v1 Announce Type: cross Abstract: Symbolic regression aims to uncover explicit scientific laws from data.
The article presents a new semantic model for representing scientific evidence, specifically tailored to genetics, that extends existing standards by adding fine‑grained, domain‑specific structure. It aligns with FHIR Evidence and SEPIO, incorporates a compact vocabulary validated by SHACL, and was tested in a human‑AI annotation pilot on six genetics papers, producing 28 evidence items and 95 source‑anchored assertions. The authors argue that this model advances trustworthy, AI‑ready infrastructure for variant interpretation by providing a reference data model and validation schema for genetic evidence.
InsightSR is a new framework that integrates Large Language Models (LLMs) with the PySR genetic programming engine to refine symbolic regression search spaces. It employs two LLM-guided pathways: a Semantic Seed Pathway that generates dimensionally consistent functional skeletons, and a Structural Feature Pathway that suggests nonlinear feature transformations. Over successive iterations, these pathways expand the input space and shift the search toward shallow, semantically informed trees, with a feedback loop that evaluates and refines candidate features. The method achieves a 95% exact recovery rate on the Feynman benchmark and 80.18% accuracy on the LLM-SRBench LSR-Transform task, outperforming existing genetic programming and neural-symbolic approaches while preserving strong out-of-distribution generalization.
arXiv:2606. 07237v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly used in healthcare for tasks such as clinical question answering, diagnosis support, and report summarization.
arXiv:2607. 08150v1 Announce Type: new Abstract: Symbolic regression (SR) discovers analytical equations from data, yielding glass-box models with directly interpretable formulas, unlike black-box methods that rely on unstable post-hoc tools such as SHAP or LIME.
arXiv:2609.12822v2 Announce Type: replace Abstract: Blinded physician evaluation has been considered by many to be the gold standard for assessing clinical reasoning in large language models (LLMs)....
arXiv:2606. 04360v1 Announce Type: cross Abstract: Symbolic regression (SR) discovers compact mathematical expressions from data, yet recent LLM-based evolutionary methods remain sample-inefficient because they rely mainly on scalar feedback such as MSE.
arXiv:2608.30165v1 Announce Type: cross Abstract: Scientific progress depends not only on finding solutions, but on learning the rules that explain why they work and using that understanding to desig...
arXiv:2606. 10279v1 Announce Type: new Abstract: Supervised fine-tuning with synthetic rationale data is widely assumed to improve language model performance on clinical prediction tasks by teaching models not just what to predict but why.
arXiv:2608.29582v1 Announce Type: cross Abstract: Current evaluations of large language models (LLMs) primarily focus on factual knowledge retrieval, overlooking the fundamental challenge of navigati...