CT‑ΔBench is a new benchmark designed to evaluate vision‑language models on longitudinal 3D medical imaging difference reporting. It provides patient‑level split data, change‑aware metrics, and physician‑validated references to assess clinically meaningful interval changes between two CT scans. The paper also introduces DeltaMed, a baseline model that directly reasons over paired CT scans, and compares it to an indirect two‑stage approach that first generates single‑timepoint reports before differencing.
By Kegeng Tang, Jingbo Wang, Shaogang Ren, Zihao Wang
Instance-Guided Report Anchoring (IGRA) is a model-agnostic module that links each abnormality instance in a chest CT to the corresponding finding in a radiology report during training, while discarding text components at inference. By reformulating free-text grounding as multi-label volumetric segmentation, IGRA allows all abnormality categories to be predicted in a single image-only forward pass. The method improves Dice scores by 22.5% over the strongest image-only baseline and matches state‑of‑the‑art performance on single-finding subsets, with consistent gains across multiple 3D segmentation backbones and datasets.
By Zhenyu Bu, Haoyan Ding, Chushu Shen, Xinyuan Zheng, Peiyu Duan, Xueqi Guo, Sepehr Farhand, Yoshihisa Shinagawa, Gerardo Hermosillo, Chaowei Wu
Vision-language pre-training (VLP) holds great promise for general-purpose medical AI by leveraging radiology reports as rich textual supervision, yet existing methods struggle with 3D CT imaging due to inefficient visual backbones and coarse semantic alignment. To address these issues, we propose a tailored VLP framework featuring three key components: (1) a CNN-ViT hybrid encoder that replaces ViT's patch embedding with a 3D CNN backbone to efficiently capture local anatomical details while preserving global attention and compatibility with pre-trained cross-modal priors; (2) a disease-level contrastive learning mechanism using learnable query tokens to dynamically extract disease-specific semantics from full reports and align them with corresponding visual features, thereby disentangling distinct diseases within the same anatomical region; and (3) a diagnosis-aware prompt strategy that employs real clinical phrases and aggregated disease prototypes to bridge the pre-training-inference gap and enhance zero-shot diagnostic reliability.
arXiv:2608. 03890v1 Announce Type: cross Abstract: A clinically useful chest X-ray system must go beyond fluent report generation: it should classify findings with tunable decision thresholds, localize them spatially, and derive the anatomical measurements upon which many diagnoses depend.
By Mercy Prasanna Ranjit, Anirban Porya, Sathvik Joel, Niharika Vadlamudi, Nikhilesh Chowdary Eathamukkala, Prasanth V V, Abhyuday Kumara Swamy, Pranay Narhari Umredkar, Pradeep Narayan, Vivek Rajagopal, Tanuja Ganu
arXiv:2607. 24743v1 Announce Type: cross Abstract: Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment.
By Hangjie Yuan, Yichen Qian, Zhiwei Tang, Xianzhe Xu, Lirong Wu, Sicheng Yang, Jinwang Wang, Pengju Wang, Zhitao Zeng, Yizeng Han, Yan Xing, Shengxuan Luo, Tao Feng, Qing Xie, Weigen Yao, Yi Yang, Zuozhu Liu, Jiasheng Tang, Shaocheng Wang, Jitao Wang, Jiahong Dong, Weihua Chen, Feng Xu, Fan Wang
Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment. In this paper, we introduce ClinFusion, a vision-centric MLLM designed for holistic medical understanding that systematically addresses these limitations.
arXiv:2609.00866v1 Announce Type: cross
Abstract: The rapid advancement of vision-language models (VLMs) has accelerated progress in computational pathology; however, whole-slide image (WSI)-based pa...
By Yumi Lee, Harim Oh, Hyoryung Kim, Minji Kim, Eunsu Kim, Hyeseong Lee, Junya Fukuoka, Andrey Bychkov, Jijgee Munkhdelger, Rajiv Kumar Kaushal, Ayushi Sahay, Rajni Yadav, Bharathi Prabakaran, Sulen Sarioglu, Serdar Balc{\i}, Ilknur Turkmen, Yuri Tolkach, Christian Harder, Julian Westerdorf, Reinhard Buettner, Audun Ljone Henriksen, Sepp De Raedt, Byung Hyun Lee, Sungjin Lim, Joohoon Lee, Gwanghyun Kim, Se Young Chun, Suryakant Singh, Saarthak Kapse, Prateek Prasanna, Kyung A Kim, Yousun Kang, Sehwan Yoo, Sungman Hong, Shubham Innani, Michael Feldman, Spyridon Bakas, Ujjwal Baid, Prasad Dutande, Suhas Gajare, Bhakti Baheti, Serkan S\"okmen, Ece Tu\u{g}ba Cebeci, Ahmet Hal{\i}c{\i}, Musa Balc{\i}, Kardelen Pe\c{c}enek, Srividhya Sainath, Kyongseok Jang, Messi H. J. Lee, Noorul Wahab, Bodong Du, Jiaming Zhang, Qixiang Zhang, Jang-Hwan Choi, Sangjeong Ahn
ASTAR is an LLM-based framework that automatically generates standardized radiology reporting templates from large-scale clinical free-text corpora, eliminating the manual, expert-driven template construction process. In experiments on 4,215 fetal brain MRI reports from multiple centers, ASTAR‑induced templates outperformed two expert‑curated templates in template coverage, information fidelity, diagnostic fidelity, and expert‑rated usability. The approach reduces template development time from weeks of committee deliberation to hours of automated processing.
By Xinfeng Zhang, Mingxuan Liu, Yifei Chen, Juncheng Zhu, Kasidit Anmahapong, Yiming Huang, Yuan Zhang, Hongjia Yang, Yi Liao, Gang Ning, Haibo Qu, Qiyuan Tian
arXiv:2510. 15042v3 Announce Type: replace-cross Abstract: In the 3D medical image domain, vision-language pre-training is used to create vision-language encoders (VLEs) that can support radiologists by retrieving patients with similar abnormalities, predicting likelihoods of abnormality, or, with downstream adaptation, generating radiological reports.
By Tassilo Wald, Ibrahim Ethem Hamamci, Yuan Gao, Sam Bond-Taylor, Harshita Sharma, Maximilian Ilse, Cynthia Lo, Olesya Melnichenko, Anton Schwaighofer, Noel C. F. Codella, Maria Teodora Wetscherek, Klaus H. Maier-Hein, Panagiotis Korfiatis, Valentina Salvatelli, Javier Alvarez-Valle, Fernando P\'erez-Garc\'ia
arXiv:2606. 31099v1 Announce Type: cross Abstract: Recent years have seen substantial advances in radiology report generation (RRG), yet existing approaches predominantly adopt direct feature fusion when handling multi-view X-ray images.
By Yucheng Chen, Jinjing Zhu, Yang Yu, Yufei Shi, Hane Naghshbandi, Jinhua Liu, Angela S. Koh, Fang Fen, Kian Eng Ong, Si Yong Yeo
The rapid advancement of vision-language models (VLMs) has accelerated progress in computational pathology; however, whole-slide image (WSI)-based pathology report generation remains limited by the sc...
arXiv:2508. 16674v2 Announce Type: replace-cross Abstract: Medical report understanding from real-world document images is essential for generating patient-facing explanations and enabling structured information exchange in clinical systems.
By Fangxin Shang, Yuan Xia, Dalu Yang, Yahui Wang, Binglin Yang