arXiv AI

VeriSim: A Configurable Framework for Stress-Testing Medical AI Under Patient Communication Noise

VeriSim is a configurable patient simulation framework that injects controllable noise across six clinically grounded communication dimensions while preserving patient medical records. It uses a verifier that extracts atomic claims from utterances and checks them against a UMLS‑grounded vector index built with BioLORD embeddings, relying on structured clinical metadata rather than surface‑text similarity. Stress‑testing seven open‑weight LLMs shows realistic noise reduces diagnostic accuracy by 15‑25 percentage points and lengthens conversations by 34‑55%, with smaller models degrading more than larger ones; expert ratings confirm VeriSim’s high truth, realism, clinical utility, and noise fidelity.

arXiv AI
Jul 29

PatientAgentBench: A Benchmark Framework for Evaluating Patient-Facing Health AI Agents

arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.

By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv Computation and Language
Oct 16

MindEval2: Clinically Grounded Patients and Rubrics for Evaluating Language Models in Mental Health Support

MindEval2 is a new evaluation framework for AI chatbots in mental health support, comprising Mental Health Quality Rubrics (MHQR) and the MindSim patient simulation harness. MHQR, developed with PhD-level psychologists, provides explicit, actionable criteria for assessing response quality, while MindSim offers realistic, longitudinal patient interactions with a memory component. The study evaluated 18 models, finding that although surface-level quality has improved, guidance calibration remains the main failure across all models.

By John Mendon\c{c}a, Daniel Tschernutter, Jos\'e Pombal, Areti Vassilopoulos, Catarina Botelho, Ignacio Sarasua, Maya D'Eon, Nuno Guerreiro, Ricardo Rei
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv AI
Sep 25

Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmark

Synthetic Hospital is an open, fully synthetic longitudinal electronic health record benchmark created from public medical education material. It contains 1,268 patients and 5,602 encounters, with every diagnosis, finding, and temporal relation grounded in standard ontologies and traceable back to its source. Physicians could not reliably distinguish its records from real charts, and current frontier AI models perform significantly below human experts on tasks such as reconstructing problem lists and summarizing charts.

By Christine Park, Valerie Chen, Tim Dettmers
arXiv AI
Jul 9

SycoEval-EM: Sycophancy Evaluation of Large Language Models in Simulated Clinical Encounters for Emergency Care

arXiv:2601. 16529v4 Announce Type: replace Abstract: Large language models (LLMs) deployed in clinical decision support may acquiesce to patient requests for care that conflicts with evidence-based guidelines.

By Dongshen Peng, Yi Wang, Austin Schoeffler, Sun-ha Hong, Brian Suffoletto, David Kim, Carl Preiksaitis, Christian Rose
arXiv Computation and Language
Sep 1

Evidence-Bounded Mental Health Reasoning from Heterogeneous Speech Protocols

The paper introduces Evidence-Bounded Mental Health Reasoning, addressing the problem that current multimodal mental health screening models treat all clinical speech protocols as equally evidential. It presents the Evidence Package Benchmark, comprising 1,870 annotated packages from six diverse protocols, and proposes EviBound, a protocol-aware framework that limits reasoning to valid evidence using a planner, acoustic consensus, and a boundary critic. EviBound outperforms existing omni-modal baselines, achieving a Depression AUROC of 0.8658 with no claim violations.

By Chengyuan Gao, Jiang Wu, Tao Lu, Jiayan Guo, Mingkun Xu, Tianyi Zang, Shangyang Li
arXiv AI
Jul 13

MedRealMM: A Real-World Multimodal Benchmark for Chinese Online Medical Consultation

arXiv:2607. 09142v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly deployed in online medical consultation, yet existing benchmarks remain poorly aligned with real clinical practice.

By Runhan Shi, Quan Zhou, Yuqian Xu, Shuai Yang, Xin Wu, Zitong Zhou, Hui Liu, Bin Cha, Zheming Wang, Liya Li, Wei Wei, Haoyuan Hu, Jun Xu
arXiv AI
Aug 18

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

arXiv:2505. 14107v5 Announce Type: replace-cross Abstract: The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios.

By Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang
arXiv AI
1d ago

MedConstBench: Benchmarking How Constitutions Steer LLMs in Medical Ethics

MedConstBench is a new medical‑ethics benchmark that treats a model’s deployment constitution as a controllable variable. It is organized around Beauchamp’s four principles and uses human‑calibrated peer review to score responses. The benchmark includes the MedDilemma dataset of clinical dilemmas and demonstrates that different constitutions influence LLM behavior in a dimension‑selective, model‑dependent way, leading to a proposed adaptive selector that chooses the best constitution per model.

By Yibo Yang, Zerui Huang, Haomiao Yang, Zixia Wang