arXiv Machine Learning

NeoTriFuse: Reliability-Aware Multimodal Fusion under Missingness Heterogeneity for Neonatal Mortality Risk Prediction

NeoTriFuse is a reliability‑aware multimodal fusion framework designed to predict neonatal mortality risk from bedside monitoring data that suffers from extreme class imbalance, heterogeneous risk factors, multi‑scale temporal dynamics, and significant missingness. The method treats missing data as an explicit reliability signal, dynamically adjusting modality contributions during fusion through gating mechanisms that incorporate static perinatal variables, local‑global temporal encoders, and patient‑level statistical summaries. NeoTriFuse achieves competitive performance (F1 ≈ 0.674, AUROC ≈ 0.945) and ablation studies show that its temporal architecture and patient‑level summary branch are key contributors, with reliability‑aware gating further improving threshold‑dependent metrics under heterogeneous observation completeness.

arXiv Machine Learning
Sep 23

Evidential Fusion Network for Multimodal Survival Prediction under Missing Modalities

The paper introduces the Evidential Missing Modality Survival Fusion (EMMS) model, which predicts survival outcomes using multimodal data even when some modalities are missing. EMMS applies Dempster‑Shafer theory and Gaussian Random Fuzzy Numbers to fuse information, accounting for both aleatoric and epistemic uncertainty and the reliability of each modality. Experiments on four cancer datasets show that EMMS achieves state‑of‑the‑art performance while providing calibrated, interpretable uncertainty estimates without extra computational cost.

By Yucheng Xing, Hailan Mo, Zi Wang, Ling Huang, Mengling Feng
arXiv Machine Learning
Jul 31

TIER-MoE: Trust-Informed Expert Routing via Conditional Modality Risk for Multimodal Fusion in Biomedical Classification

arXiv:2607. 27289v1 Announce Type: new Abstract: The promise of multimodal fusion lies in combining complementary sources of evidence, yet more evidence does not always yield a better prediction.

By Yu Chang, Anzhe Cheng, Chenwei Wu, Zhuoran Wang, Jiahao Chen, Tamoghna Chattopadhyay, Sophia I. Thomopoulos, Paul M. Thompson, Liyue Shen, Paul Bogdan
arXiv Machine Learning
Jul 24

Multimodality Stacking with Blockwise missing values and application to the PIONeeR biomarkers study for prediction of resistance to immunotherapy

arXiv:2605. 25050v2 Announce Type: replace-cross Abstract: Integrating multimodal datasets in clinical oncology is frequently hindered by high dimensionality and blockwise missingness, where entire data sources are unavailable for specific patient subsets.

By Mohamed Boussena, Florence Monville, Jacques Fieschi-Meric, Frederic Vely, Pierre Milpied, Julien Mazieres, Maurice Perol, Eric Vivier, Laurent Greillier, Fabrice Barlesi, Sebastien Benzekry
arXiv AI
Sep 24

A Leakage-Aware Multimodal Evaluation Framework for Early Intraoperative Acute Kidney Injury Prediction

The study introduces SynerT, a waveform-only hybrid temporal model that uses a causal dilated TCN and dilated recurrent layers to predict early intraoperative acute kidney injury (AKI). Two extensions, SynerT-MM and SynerT-Stack, incorporate hemodynamic summaries, preoperative covariates, and a leakage-safe stacked ensemble to improve discrimination and calibration. Evaluated on the VitalDB database with a strict 60‑minute prediction window, SynerT-Stack achieved the best performance across AUROC, AUPRC, and F1‑max, and demonstrated the greatest net clinical benefit after recalibration.

By Quang Minh Nguyen, Duc Minh Le, Ho Nhat Minh Nguyen, Thuy Quynh Nguyen, Trong Nghia Nguyen
arXiv Computer Vision
Sep 7

Real-World Multi-Modal and Longitudinal Lung Cancer Dataset

The paper presents a newly curated, multi-center, multi-modal, and longitudinal lung cancer dataset comprising 1,365 patients with whole-slide images, CT scans, PET scans, structured clinical data, transcriptomics, and follow-up information. The dataset features substantial, non-uniform missingness across modalities, making it ideal for evaluating robust multi-modal fusion strategies. Benchmarks on 12‑month overall survival, disease‑specific survival, and longitudinal hazard prediction demonstrate that integrating complementary modalities consistently outperforms uni-modal approaches, even under severe missing data.

By Rita Cordeiro Mendes, Maria Rita Fonseca Verdelho, Carlos Santiago, Catarina Barata