HD-Prot: A Protein Language Model for Joint Sequence-Structure Modeling with Continuous Structure Tokens
arXiv:2512. 15133v3 Announce Type: replace-cross Abstract: Proteins inherently possess a consistent sequence-structure duality.
arXiv:2512. 15133v3 Announce Type: replace-cross Abstract: Proteins inherently possess a consistent sequence-structure duality.
arXiv:2606. 09962v1 Announce Type: cross Abstract: Continuous diffusion for categorical data is a framework belonging to the diffusion family and aiming at generating discrete data.
arXiv:2604. 04287v2 Announce Type: replace Abstract: Foundation models in genomics have shown mixed success compared to their counterparts in natural language processing.
arXiv:2606. 08417v1 Announce Type: cross Abstract: Diffusion and continuous flow-based language models have emerged as the leading non-autoregressive alternatives to language modeling.
arXiv:2610.22763v1 Announce Type: new Abstract: Bayesian optimization (BO) over discrete spaces is challenging due to missing gradients and the sparsity of valid solutions. Latent-space BO sidesteps...
arXiv:2606. 18997v1 Announce Type: new Abstract: Uncovering the true informational architecture of real-world complex systems requires disentangling how their components uniquely store, redundantly share, and synergistically integrate information over time.
arXiv:2503. 07154v3 Announce Type: replace-cross Abstract: Generative pre-training is often framed through a false dichotomy between autoregressive models for discrete signals and diffusion models for continuous signals.
The paper presents a theoretical analysis of score mismatch in discrete diffusion models, deriving a KL divergence upper bound that quantifies the bias introduced when the training and target distributions differ. It examines partial-observation constraints such as text infilling and sentence completion, showing that the Conditional SEDD sampler can incur a bias that grows with dimension, vocabulary size, and compatibility. To mitigate this, the authors propose a Randomized Hard Clamping (RHC) sampler for coordinatewise set constraints, demonstrating through experiments that it effectively reduces bias and improves sampling performance.
arXiv:2608.20635v1 Announce Type: cross Abstract: Discrete diffusion models have demonstrated strong performance across a range of datasets, including natural language data and graph-structured data....
arXiv:2602. 20293v3 Announce Type: replace Abstract: We study a discrete denoising diffusion framework that integrates a sample-efficient estimator of single-site conditionals with round-robin noising and denoising dynamics for generative modeling over discrete state spaces.
arXiv:2608.23551v1 Announce Type: cross Abstract: Recent advances in continuous diffusion and flow-based language models (LMs) have achieved performance competitive with discrete LMs. However, existi...
arXiv:2607. 16725v1 Announce Type: cross Abstract: Conditional generative modeling remains a challenging problem in semi-supervised settings where labeled data is scarce but unlabeled samples are abundant.