arXiv Machine Learning

CoMedBench: A Multi-Source Benchmark of Synthetic Medical Data Fidelity and Downstream Utility

arXiv:2608. 12805v1 Announce Type: new Abstract: Access to clinical data is essential for developing reliable healthcare machine learning systems, but direct use of electronic health records is constrained by privacy regulation, institutional review, data-use agreements, and the risk of re-identification.

arXiv AI
Aug 7

Improving the Realism of Synthetic Clinical Benchmarks Under Utility Constraints

arXiv:2608. 06265v1 Announce Type: new Abstract: Synthetic clinical benchmarks for enterprise AI agents can pass existing utility checks and still remain structurally unrealistic, especially in privacy-sensitive healthcare settings where operational data are hard to access.

By Omid Bazgir, Md Nasir, Jacob Hoffman, Yang Yang, Manu Agrawal, Anusua Trivedi, Vinay Rao Dandin, Chris Gibbons, Christine Swisher
arXiv AI
Jun 8

REMEDI: A Benchmark for Retention and Unlearning Evaluation in Multi-label Clinical Disease Inference

arXiv:2606. 07141v1 Announce Type: cross Abstract: Language models trained for clinical disease inference are trained on patient data, which may include sensitive and private information, and data owners may request the removal of their data from a trained model due to privacy or copyright concerns.

By Anurag Sharma, Sai Teja Chunchu, Prasenjit Mitra, Sandipan Sikdar, Koustav Rudra
arXiv AI
Jul 23

SynPre-FL: Synthetic data-driven pretraining integrated Federated Learning training framework

arXiv:2607. 19524v1 Announce Type: cross Abstract: Federated learning (FL) offers a promising approach to privacy-preserving clinical risk prediction, but its deployment remains limited by restricted data sharing, client heterogeneity, class imbalance, and the lack of realistic tabular electronic health record (EHR) benchmarks.

By Akarsh K Nair, Muhammad Arifur Rahman, Nicholas Shopland, Andy Burton, Jun He, Yuan Shen, David Baldwin, Emma O'Dowd, Amna Burzic, Mufti Mahmud, David J. Brown
arXiv AI
Sep 10

TabBench-Bio: A Living Benchmark for Machine Learning on High-Dimensional Biomedical Tables

TabBench-Bio is a living, interactive benchmark that evaluates machine learning models on 43 high‑dimensional biomedical tables, covering multiple domains. Using a shared cross‑validation protocol, the benchmark compares classical estimators, neural networks, and tabular foundation models across 28 feature‑by‑sample operating points, with RealTabPFN v2.5 achieving the highest performance at the reference cell of 10,000 features and 100 training samples. The benchmark provides reproducible results, fold‑level predictions, and invites community contributions to expand its dataset collection.

By Jules Kreuer, Sofiane Ouaari, Julia Hellmig, Julius Braitinger, Nico Pfeifer
arXiv AI
Aug 11

FoMoH: A clinically meaningful foundation model evaluation for structured electronic health records

arXiv:2505. 16941v4 Announce Type: replace-cross Abstract: Foundation models (FMs) promise to address core limitations of traditional supervised machine learning: (i) reliance on large amounts of labeled data, (ii) task specificity, and (iii) poor transportability.

By Vincent Jeanselme, Zilin Jing, Aparajita Kashyap, Chao Pang, Florent Pollet, Young Sang Choi, Xinzhuo Jiang, Yuta Kobayashi, Yanwei Li, Sara Matijevic, Karthik Natarajan, Shalmali Joshi
arXiv AI
Jul 23

Recovering Clinical Utility Under Differential Privacy: Empirical Validation of Adaptive Federated Aggregation on Heterogeneous Cardiovascular Datasets

arXiv:2607. 19403v1 Announce Type: cross Abstract: Validating federated learning frameworks on real clinical data is an essential step between proof-of-concept demonstrations in controlled synthetic environments and deployment in real multicenter healthcare settings.

By Rodrigo Tertulino, Laercio Alencar, Ricardo Almeida
arXiv Machine Learning
Jul 20

LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models

arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.

By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv Machine Learning
Jul 2

A Filtered Mixture-of-Generators for Fully Synthetic Survival Training

arXiv:2607. 00127v1 Announce Type: new Abstract: Survival analysis models time-to-event data, but in clinical settings training data are costly and scarce: events accrue over years of follow-up, cohorts are small, and privacy regulations restrict sharing across institutions.

By Niccol\`o Maria Rizzi, Eugenio Lomurno, Alberto Archetti, Matteo Matteucci
arXiv Machine Learning
Jul 31

Psych-ECA: A Reproducible Semi-Synthetic Benchmark for Synthetic Control Arms in Longitudinal Psychiatry

arXiv:2607. 27224v1 Announce Type: cross Abstract: External and synthetic control arms (ECAs) are entering psychiatric drug development, but the field lacks a benchmark that evaluates the properties regulators care about: not only how accurately a method reconstructs untreated trajectories, but whether its uncertainty is calibrated, whether it is robust to the informative observation times common in mental-health records (sicker patients are seen more often), and what false-positive rate it induces in go/no-go trial decisions.

By Aakash Bhagat, Shashank Choudhary