The study introduces a scaffolding-oriented multi-agent Large Language Model (LLM) AI Standardized Patient (AI-SP) platform designed to train medical students in patient interviews. In a randomized controlled trial with 100 students, the multi-agent system—comprising a patient agent, a Socratic tutor agent, and a turn-level evaluator—did not improve diagnostic accuracy but significantly enhanced overall OSCE scores, especially in communication, empathy, and history-taking. The authors also release a richly annotated dataset to support further research in AI-supported clinical reasoning training.
By Luming Yang, Haoxian Liu, Siqing Li, Rong Jia, Yue Xiao, Guanhua Chen, Li Lu
arXiv:2606. 28900v1 Announce Type: new Abstract: Doctor agents are moving beyond single-turn answer generation toward evolving clinical decision systems.
By Hui Zhang
arXiv:2606. 17474v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly considered for use in clinical consultation tasks, yet most medical evaluations remain static, single-turn, or narrowly outcome-based, limiting their ability to reflect the sequential, uncertain, and interactive nature of real-world care.
By Jiahui Niu, Huizi Yu, Wenkong Wang, Guangxin Dai, Jingxian He, Xiang Li, Zhiying Liang, Xinxin Lin, Kent CY So, Bryan YP Yan, Yun Kwok Wing, Yanqiu Xing, Xin Ma, Lizhou Fan
arXiv:2602.01995v2 Announce Type: replace
Abstract: Conversational diagnosis requires multi-turn history-taking, where an agent asks clarifying questions to refine differential diagnoses under incomp...
By Jeongmoon Won, Seungwon Kook, Yohan Jo
arXiv:2603. 25821v3 Announce Type: replace-cross Abstract: We present Doctorina MedBench, an evaluation framework for agent-based medical AI based on the simulation of physician-patient interactions.
By Anna Kozlova, Stanislau Salavei, Pavel Satalkin, Hanna Plotnitskaya, Sergey Parfenyuk, Andy Nkansah
arXiv:2607. 18999v1 Announce Type: cross Abstract: Multi-turn medical consultation agents must decide what to ask, adapt to patient responses, and determine when the collected evidence is sufficient.
By Guofeng Zhang, Yizeng Quan, Huaiyi Fang, Jianwei Lv, Jinyao Liu, Xunxu Duan, Lening An, Yu Ouyang, Junfeng Wang
arXiv:2608. 07511v1 Announce Type: cross Abstract: Background.
By Dorothee Amelung, Andrew M. Bean, Sabine C. Herpertz, Felix H. Krones, Guy Parsons, Adam Mahdi, Isabella Schneider
arXiv:2603. 25821v2 Announce Type: replace-cross Abstract: We present Doctorina MedBench, a comprehensive evaluation framework for agent-based medical AI based on the simulation of realistic physician-patient interactions.
By Anna Kozlova, Stanislau Salavei, Pavel Satalkin, Hanna Plotnitskaya, Sergey Parfenyuk
The paper introduces Expected‑Severity‑Risk (ESR), a new objective for selecting questions in proactive medical dialogue that prioritizes reducing the expected severity of diagnostic errors rather than merely uncertainty. ESR uses population statistics to marginalize over possible answers and distills its rankings into a prefix‑only language policy, enabling deployment without teacher‑side risk computation. Experiments on DDxPlus show ESR cuts high‑severity diagnostic misses by 29.5% and boosts accuracy while adding only 0.14 extra questions per dialogue.
By Chenxuan Li, Xinrong Chen, Luyan Zhang, Peidong Jia, Runfan Zheng, Zhongyu Zhao, Xuecheng Shang, Peixing Wan
arXiv:2606. 20164v1 Announce Type: cross Abstract: Real-world clinical decision support requires reasoning over heterogeneous and longitudinal patient information rather than answering isolated medical questions.
By Aueaphum Aueawatthanaphisut
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
MedConceal is a new benchmark for evaluating medical dialogue systems on hidden‑concern reasoning under partial observability. It features 300 curated cases and 600 clinician‑LLM interactions, using an interactive patient simulator that hides latent concerns and tracks their revelation and resolution through theory‑grounded communication signals. The benchmark assesses both confirmation (surfacing hidden concerns) and intervention (addressing the primary concern), revealing that current models excel on different metrics while human clinicians still outperform them on intervention success.
By Yikun Han, Joey Chan, Jingyuan Chen, Mengting Ai, Simo Du, Yue Guo