arXiv:2608. 06659v1 Announce Type: new Abstract: This paper shows that latent-space predictive pretraining can provide a scalable route to foundation models for spatial transcriptomics.
By Haiping Liu, Qian Zhao, Lijing Lin, Jingyuan Sun, Hongpeng Zhou
arXiv:2607. 09166v1 Announce Type: new Abstract: Spatial transcriptomics enables profiling of spatial gene expression but is limited by high cost and low throughput, motivating prediction from H&E histopathology images.
By Keunho Byeon, Sunhong Park, Jeewoo Lim, Jin Tae Kwak
arXiv:2608. 14710v1 Announce Type: cross Abstract: Predicting spatial gene expression from hematoxylin and eosin (H\&E)-stained images offers a cost-effective alternative to spatial transcriptomics (ST).
By Ruochen Liu, Wei Lou
arXiv:2608. 14924v1 Announce Type: cross Abstract: Spatial transcriptomics (ST) links tissue morphology with molecular programs, motivating multimodal pretraining methods that align histology images with gene expression.
By Azim Dehghani Amirabad, Junchao Zhu, Pushpak Pati, Walid Abdelmoula, Tommaso Mansi, Rui Liao
arXiv:2507. 04704v3 Announce Type: replace-cross Abstract: Understanding how cellular morphology, gene expression, and spatial context jointly shape tissue function is a central challenge in biology.
By Zhenglun Kong, Mufan Qiu, John Boesen, Xiang Lin, Sukwon Yun, Tianlong Chen, Manolis Kellis, Marinka Zitnik
arXiv:2603. 13432v4 Announce Type: replace-cross Abstract: Spatial Transcriptomics (ST) profiles thousands of gene expression values at discrete spots with precise coordinates on tissue sections, preserving spatial context essential for clinical and pathological studies.
By Yishun Zhu, Jiaxin Qi, Jian Wang, Yuhua Zheng, Jianqiang Huang
arXiv:2506. 11152v4 Announce Type: replace-cross Abstract: Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell level.
By Hiren Madhu, Jo\~ao Felipe Rocha, Tinglin Huang, Siddharth Viswanath, Smita Krishnaswamy, Rex Ying
arXiv:2606. 08712v1 Announce Type: cross Abstract: Purpose: Spatial transcriptomics (ST) enables gene expression measurements within the tissue context.
By Hongyi Yu, Yaoyu Fang, Jiahe Qian, Xinkun Wang, Lee A. Cooper, Bo Zhou
arXiv:2606. 02424v1 Announce Type: cross Abstract: Histology-based single-cell spatial transcriptomics (ST) estimation aims to predict gene expression for individual cells from histopathological images and cell locations, reducing the need for costly single-cell ST measurements.
By Kaito Shiku, Ahtisham Fazeel Abbasi, Ryoma Bise, Yuichiro Iwashita, Kazuya Nishimura, Andreas Dengel, Muhammad Nabeel Asim
arXiv:2602. 04901v2 Announce Type: replace-cross Abstract: Predicting transcriptional responses to genetic perturbations is a central problem in functional genomics.
By Jiafa Ruan, Ruijie Quan, Liyang Xu, Zongxin Yang, Yi Yang
arXiv:2606. 03644v1 Announce Type: new Abstract: Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times.
By Fengtao Zhou, Yingxue Xu, Zhengyu Zhang, Yihui Wang, Zhengrui Guo, Ling Liang, Jiabo Ma, Cheng Jin, Ziyi Liu, Huajun Zhou, Hongyi Wang, Du Cai, Chenglong Zhao, Xi Wang, Can Yang, Yu Wang, Wenbin Li, Feng Gao, Zhe Wang, Zhenhui Li, Xiuming Zhang, Li Liang, Hao Chen
arXiv:2607. 14410v1 Announce Type: new Abstract: Spatially resolved omics studies increasingly combine transcriptomic and epigenomic assays, yet downstream analysis is often still performed using single-modality pipelines.
By Jagan Mohan Reddy Dwarampudi, Veena Kochat, Suresh Satpati, Kunal Rai, Tania Banerjee