The paper presents EpidemIA, a training‑free AI Multi Agent System that lets clinicians and administrators use epidemiological models and perform statistical analyses through natural language conversations. The system runs on a single‑GPU workstation, employs a locally hosted open‑weights LLM to keep data private, and includes a modular suite of expert‑written models. Using Emergency Department visit data from IRCCS Sant’Orsola, the authors demonstrate that users can conduct both simple statistical queries and complex dynamical predictions via natural language.
The Epydemix Agent Framework adds an AI‑friendly layer to the Epydemix Python library for stochastic epidemic modeling. It provides four key features: model and parameter discovery, declarative scenario validation, execution via tested code, and result inspectability, enabling an AI agent to manage the entire modeling workflow from natural‑language input to quantitative outputs. The authors demonstrate the framework with a vaccination strategy case study and evaluate it over 50 agent sessions, showing reductions in turns, output tokens, and cost compared to direct Python use.
By Nicol\`o Gozzi, Ciro Cattuto, Alessandro Vespignani
arXiv:2610.34878v1 Announce Type: new
Abstract: Disease diagnosis is a key application of large language model (LLM) agents in healthcare. However, existing medical agents are primarily trained and e...
By Sirry Chen, Fangke Chen, Xuanwen Ding, Wei Chen, Zhongyu Wei
Disease diagnosis is a key application of large language model (LLM) agents in healthcare. However, existing medical agents are primarily trained and evaluated with static question-answering data, pro...
arXiv:2607. 06757v1 Announce Type: new Abstract: Agent-based modeling (ABM) has the capability to model millions of individuals and their interactions, which is useful for policy making.
By Sifat Afroj Moon, Dakotah Maguire, Adam Spannaus, Joe Tuccillo, Maksudul Alam, Sudip K. Seal, John Gounley, Heidi Hanson
arXiv:2608. 11420v1 Announce Type: new Abstract: Medical diagnostic reasoning is a high-impact use case for LLMs that carries significant implications for the health and wellbeing of users.
By Del Coburn, Scott Sanner, Dan Silver
arXiv:2610.02744v1 Announce Type: new
Abstract: Epidemic intervention policies are textual artefacts that human decision-makers interpret, justify, and revise through natural language, making large l...
By Zeeshan Memon, Yiqi Su, Kai Shu, Naren Ramakrishnan, Liang Zhao
The article surveys how large language models (LLMs) are being applied to mental health, outlining a three‑phase evolution: Phase I uses LLMs as passive information tools and pattern recognizers for assessment; Phase II employs them as empathetic conversationalists for stateless, in‑the‑moment interactions; Phase III aims to create longitudinal, personalized companions that act as stateful cognitive agents. It systematically reviews core technologies, agent architectures (Profile, Memory, Reasoning, Planning), and the datasets and benchmarks that support this progression, offering a coherent narrative and roadmap for future research. The survey also provides a curated resource list at https://github.com/Emo-gml/Awesome-Mental-Health-LLMs.
By He Hu, Yucheng Zhou, Qianning Wang, Yingjian Zou, Chiyuan Ma, Juzheng Si, Jianzhuang Liu, Zitong Yu, Laizhong Cui, Fei Ma, Qi Tian
arXiv:2606. 16149v3 Announce Type: replace Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer; off-the-shelf large language models (LLMs) rank the correct disease first in only 35.
By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
arXiv:2606.16149v5 Announce Type: replace
Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer. Large language models rank the correct disease first i...
By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh F. Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
The paper introduces MACD, a Multi-Agent Clinical Diagnosis framework that enables large language models to self‑learn clinical knowledge through a multi‑agent pipeline of summarization, refinement, and application. MACD is extended into a human‑AI collaborative workflow where multiple diagnostician agents consult iteratively, guided by a judge agent and human oversight. Evaluation on the MIMIC‑MACD cohort shows significant gains in diagnostic accuracy—an average 11.6 percentage‑point improvement over authoritative knowledge for open‑weight LLMs and an 18.3‑percentage‑point boost over physician‑only diagnosis in text‑only vignettes.
By Wenliang Li, Rui Yan, Xu Zhang, Li Chen, Hongji Zhu, Jing Zhao, Junjun Li, Mengru Li, Wei Cao, Zihang Jiang, Wei Wei, Kun Zhang, Shaohua Kevin Zhou
The paper introduces MIMIC-DOS, a dataset derived from MIMIC-IV that focuses on ICU cases where patient symptoms and medical signs are discordant. It presents CARE, a privacy‑compliant multi‑stage agentic reasoning framework that uses a proprietary LLM to generate structured categories and transitions, while a local LLM performs evidence acquisition and decision‑making. In retrospective evaluations on MIMIC‑DOS, CARE outperforms other LLMs and agentic workflows, demonstrating stronger handling of conflicting clinical evidence while preserving patient privacy.
By Haochen Liu, Weien Li, Rui Song, Zeyu Li, Chun Jason Xue, Xiao-Yang Liu, Sam Nallaperuma-Herzberg, Xue Liu, Ye Yuan