arXiv AI

General Demographic Pre-trained Models for Enhancing Predictive Performance Across Diseases and Population

The paper introduces the General Demographic Pre-trained (GDP) model, a lightweight foundation model that learns representations from the two most common clinical attributes—age and sex. By optimizing encoding and visit‑reordering strategies, GDP embeddings are shown to improve predictive performance when concatenated with raw features across various disease and geographic cohorts. The model outperforms several state‑of‑the‑art tabular foundation models and tree‑based algorithms, demonstrating that enriched demographic embeddings can enhance classification tasks while remaining fully compatible with standard classifiers.

arXiv AI
Jun 2

Retrieval-aligned Tabular Foundation Models Enable Robust Clinical Risk Prediction in Electronic Health Records Under Real-world Constraints

arXiv:2604. 01841v2 Announce Type: replace Abstract: Clinical prediction from structured electronic health records (EHRs) is challenging due to high dimensionality, heterogeneity, class imbalance, and distribution shift.

By Minh-Khoi Pham, Thang-Long Nguyen Ho, Thao Thi Phuong Dao, Tai Tan Mai, Minh-Triet Tran, Marie E. Ward, Una Geary, Rob Brennan, Nick McDonald, Martin Crane, Marija Bezbradica
arXiv AI
Aug 11

FoMoH: A clinically meaningful foundation model evaluation for structured electronic health records

arXiv:2505. 16941v4 Announce Type: replace-cross Abstract: Foundation models (FMs) promise to address core limitations of traditional supervised machine learning: (i) reliance on large amounts of labeled data, (ii) task specificity, and (iii) poor transportability.

By Vincent Jeanselme, Zilin Jing, Aparajita Kashyap, Chao Pang, Florent Pollet, Young Sang Choi, Xinzhuo Jiang, Yuta Kobayashi, Yanwei Li, Sara Matijevic, Karthik Natarajan, Shalmali Joshi
arXiv Computation and Language
Aug 25

Scaling Electronic Health Record Foundation Models for Population Health Management

The paper introduces Scaling Electronic Health Record Foundation Models for Population Health Management, a large‑scale model trained on billions of medical events from over 5 million patients in Taiwan and the United States. By aligning ICD codes across different health systems, the model achieves strong scaling and generalization across 11 chronic disease prediction tasks, outperforming tree‑based, general, and biomedical language models with high sensitivity at 99% specificity. It also demonstrates superior few‑shot performance on the EHRShot benchmark and shows that cross‑system alignment provides a stronger pretraining signal than single‑site duplication in data‑limited scenarios.

By Liwen Sun, Hao-Ren Yao, Ophir Frieder, Xiang Qian, Chenyan Xiong
arXiv Machine Learning
Jul 20

LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models

arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.

By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv AI
Jul 23

SynPre-FL: Synthetic data-driven pretraining integrated Federated Learning training framework

arXiv:2607. 19524v1 Announce Type: cross Abstract: Federated learning (FL) offers a promising approach to privacy-preserving clinical risk prediction, but its deployment remains limited by restricted data sharing, client heterogeneity, class imbalance, and the lack of realistic tabular electronic health record (EHR) benchmarks.

By Akarsh K Nair, Muhammad Arifur Rahman, Nicholas Shopland, Andy Burton, Jun He, Yuan Shen, David Baldwin, Emma O'Dowd, Amna Burzic, Mufti Mahmud, David J. Brown
arXiv AI
Jun 16

Hierarchical Modeling of ICD Codes in EHR Foundation Models

arXiv:2606. 15447v1 Announce Type: new Abstract: Electronic health record foundation models typically treat ICD diagnosis codes as flat tokens, overlooking the clinically meaningful hierarchical structure that captures disease families, subcategories, and fine-grained diagnostic detail.

By Megha Thukral, Dong Gyun Kang, Rudra Pratap Singh, Shruthi Kashinath Hiremath, Katrin H\"ansel, Thomas Pl\"otz
arXiv AI
Sep 1

Scalable Clinical Data Infrastructure and Comparative ML Evaluation for Hospitalisation Risk Prediction in Elderly Patients with Multiple Long-Term Conditions using CPRD

arXiv:2608.29419v1 Announce Type: cross Abstract: Deep learning architectures are increasingly proposed for patient trajectory modeling in electronic health records (EHRs), yet their advantage over s...

By Asra Aslam, Volodymyr Chapman, Maurice M. O'Connell, Aseel S. Abuzour, Michael Abaho, Danushka Bollegala, Gary Leeming, Eduard Shantsila, Andrew Clegg, Lauren E. Walker, Iain Edward Buchan, Samuel D. Relton
arXiv AI
Jun 2

Towards a General Intelligence and Interface for Wearable Health Data

arXiv:2605. 22759v2 Announce Type: replace Abstract: While ubiquitous wearable sensors capture a wealth of behavioral and physiological information, effectively transforming these signals into personalized health insights is challenging.

By Girish Narayanswamy, Maxwell A. Xu, A. Ali Heydari, Samy Abdel-Ghaffar, Marius Guerard, Kara Vaillancourt, Zhihan Zhang, Jake Garrison, Levi Albuquerque, Dimitris Spathis, Hong Yu, Hamid Palangi, Xuhai "Orson" Xu, David G. T. Barrett, Joseph Breda, Jed McGiffin, Yubin Kim, Yuwei Zhang, Naghmeh Rezaei, Samuel Solomon, Karan Ahuja, Tim Althoff, Jake Sunshine, Ming-Zher Poh, Benjamin Yetton, Ari Winbush, Nicholas B. Allen, James M. Rehg, Isaac Galatzer-Levy, Yun Liu, John Hernandez, Anupam Pathak, Conor Heneghan, Yuzhe Yang, Ahmed A. Metwally, Pushmeet Kohli, Mark Malhotra, Shwetak Patel, Xin Liu, Daniel McDuff