arXiv:2609.15888v1 Announce Type: cross Abstract: Deep networks trained on structural MRI for Alzheimer's disease (AD) staging often reach reasonable accuracy while attending to anatomically irreleva...
arXiv:2610.33416v1 Announce Type: new Abstract: Accurate assessment of Alzheimer's disease stages from MRI is important for understanding disease progression and supporting the development of compute...
The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
arXiv:2608. 11762v1 Announce Type: cross Abstract: Alzheimer's disease is a leading cause of death with no cure.
The paper presents a multimodal 3D convolutional neural network that classifies Alzheimer’s disease using raw OASIS 1 MRI volumes. It fuses structural T1 images with gray matter, white matter, and cerebrospinal fluid probability maps to capture complementary neuroanatomical information. Evaluated with 5‑fold subject‑level cross‑validation, the model achieves a mean accuracy of 72.34 % and an ROC AUC of 0.7781, with GradCAM visualizations highlighting anatomically relevant regions such as the medial temporal lobe and ventricles.
arXiv:2606. 29106v1 Announce Type: cross Abstract: Neurological disorders involve diverse pathologies of the brain and nervous system, making early and accurate detection essential.
This study examined whether augmenting brain tumor MRI datasets with class‑specific DCGAN‑generated images improves classification performance. Using 7,200 scans across four tumor categories, a Swin Transformer classifier trained on real images alone achieved 96% accuracy, identical to the model trained with 500 synthetic images per class. Metrics such as macro F1 and ROC‑AUC showed no improvement, and FID scores indicated substantial distributional differences between real and synthetic images.
arXiv:2606. 20037v1 Announce Type: new Abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide.
Neurological disorders involve diverse pathologies of the brain and nervous system, making early and accurate detection essential. While many deep CNNs have been developed for MRI-based classification of neurological disorders, most are optimized for binary tasks and often fail to capture the multi-class features needed to distinguish subtle anatomical differences across conditions.
MINT (Multimodal Imaging-to-Speech Knowledge Transfer) is a three-stage framework that transfers MRI-derived biomarkers to speech representations for early Alzheimer’s screening. An MRI teacher creates a compact embedding space for CN‑versus‑MCI classification, and a residual projection head aligns speech features to this space using a geometric loss, allowing imaging‑free inference. Experiments on ADNI‑4 show that aligned speech matches speech baselines, while multimodal fusion outperforms MRI alone, and ablations highlight dropout regularization and self‑supervised pretraining as key design choices.
arXiv:2607. 26746v1 Announce Type: cross Abstract: Accurate identification of Alzheimers disease (AD) using resting-state functional magnetic resonance imaging (rs-fMRI) remains challenging due to the high dimensionality, noise, and complex inter-regional dependencies inherent in functional brain connectivity, which limit the effectiveness of traditional approaches based on handcrafted connectivity features or conventional machine learning models.
The study investigates whether a compact, supervised 3D CNN pretrained for brain‑age prediction can act as a reusable foundation model for various Alzheimer's‑related neuroimaging tasks. By freezing the 7.18 million weights and adding only ~1 % of trainable parameters via Low‑Rank Adaptation, the model achieved high performance across six experiments, including dementia classification, MCI progression prediction, amyloid positivity detection, and volume estimation of hippocampal and white matter hypointensities. The results demonstrate that the pretrained brain‑age model generalizes well to new datasets without retraining, offering a data‑efficient alternative to larger networks.