The paper introduces Φ-Omni, a self‑supervised learning framework for computational pathology that disentangles synergistic information across histology, genomics, and clinical reports using Partial Information Decomposition. By employing a Synergistic Information Bottleneck and a ΦID objective, the method suppresses redundant signals while maximizing irreducible cross‑modal synergy, leading to improved few‑shot performance on breast and lung whole‑slide image datasets. The authors demonstrate that Φ-Omni outperforms both supervised and other SSL baselines on eight external tasks.
arXiv:2605. 23995v2 Announce Type: replace-cross Abstract: Self-supervised learning (SSL) has emerged as a promising paradigm for addressing the annotation bottleneck in medical imaging by learning representations from unlabeled data.
arXiv:2605. 23995v4 Announce Type: replace-cross Abstract: Self-supervised learning (SSL) is increasingly used in medical image analysis to reduce dependence on costly expert annotations by learning transferable representations from unlabeled data.
arXiv:2608.00231v2 Announce Type: replace Abstract: Volumetric CT vision-language pretraining learns 3D representations from scan-report pairs, but global and anatomy-aware objectives supervise only...
arXiv:2604. 26283v3 Announce Type: replace-cross Abstract: High-precision medical diagnosis relies not only on static imaging features but also on the implicit diagnostic memory experts instantly invoke during image interpretation.
The paper introduces TAP-JEPA, a joint‑embedding predictive architecture trained on over 113,000 CT volumes, which achieves performance comparable to leading encoders in scan‑level classification. It demonstrates a predictability bias: while anatomy is largely predictable from context, pathology is not, leading to significant degradation in pathology detection when predictions are applied. The study audits the model’s predictive pathway, showing that pathology representations shift toward control regions and that removing pathology tokens minimally affects downstream decisions, underscoring that contextual predictability alone is insufficient for clinical relevance.
arXiv:2603. 18846v3 Announce Type: replace-cross Abstract: Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL).
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
M$^2$PFN is an end‑to‑end multimodal framework that extends the TabPFN in‑context learning engine to Alzheimer’s disease diagnosis by aligning 3D‑MRI and tabular features in a shared subspace. It performs differentiable inference through TabPFN’s transformer, back‑propagates gradients into the encoders, and incorporates a frozen tabular‑only prediction via a gated shortcut. On the ADNI cohort it achieves 65.55 % macro‑F1 and 82.21 % macro‑AUC, surpassing unimodal and multimodal baselines, and it generalizes to external cohorts without retraining.
arXiv:2608. 19788v1 Announce Type: cross Abstract: Trustworthy multimodal fusion in clinical settings requires handling incomplete and heterogeneous modality subsets across institutions, where privacy constraints prohibit centralized data sharing.
Multimodal fusion learning (MFL) has shown great potential in the medical domain, where we are faced with disparate data modalities such as imaging, clinical records, and omics. However, existing MFL strategies face several major challenges.
arXiv:2606. 29102v1 Announce Type: cross Abstract: Jointly learning to segment and classify medical images demands cross-task synergy, yet encoder-sharing architectures limit decoder reconstruction to task-private representations, permanently discarding the boundary cues and semantic priors each branch could supply to the other.
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.