arXiv:2606. 07760v1 Announce Type: new Abstract: Understanding cellular phenotypes and how they respond to perturbations is critical for disease biology and therapeutic design.
By Alma Andersson, Aya Abdelsalam Ismail, Edward De Brouwer, Doron Haviv, Tommaso Biancalani, Kyunghyun Cho, Gabriele Scalia, A\"icha BenTaieb, Hector Corrada Bravo
arXiv:2606. 27752v1 Announce Type: new Abstract: Single-cell perturbation models can reduce costly wet-lab screening by predicting how cells respond transcriptionally to interventions.
By Dongxia Wu, Mingyu Li, Yuhui Zhang, Anurendra Kumar, Emma Lundberg, Serena Yeung-Levy, Emily B. Fox
arXiv:2606. 11286v1 Announce Type: cross Abstract: High-content imaging assays quantify cellular responses to chemical and genetic perturbations, yet continuous trajectories of individual cells are unobservable because cells are chemically fixed at acquisition.
By Xurui Wang, Qin Ren, Jun Ma, Haibin Ling, Chenyu You
arXiv:2606. 12838v1 Announce Type: cross Abstract: Predicting single-cell transcriptional responses to genetic, chemical and cytokine perturbations is a fundamental challenge in computational biology and AI Virtual Cell (AIVC) modeling, with direct implications for drug discovery and the elucidation of gene regulatory networks.
By Danning Jiang, Zheming An, Yalong Zhao, Lipeng Lai
arXiv:2606. 07676v1 Announce Type: cross Abstract: Spatial transcriptomics (ST) is a powerful tool for exploring biological properties dependent on structure, proximity, and interaction in tissue.
By Joseph Boyd, Matthew Lyon, Martino Mansoldo, Christian Hurry, Finnian Firth
arXiv:2608. 11269v1 Announce Type: cross Abstract: Omics datasets, particularly single-cell RNA sequencing data, are high-dimensional, sparse, noisy, and dominated by zero values, making faithful low-dimensional representation challenging.
By Fenosoa Randrianjatovo, Maya Saleh, Simon Girard, Amadou Barry