arXiv AI
1d ago

Thalamus-Reasoning: A Multimodal Large Language Model for Multi-Sample Omics Reasoning

Thalamus‑Reasoning is a 9B multimodal large language model that embeds bulk or single‑cell transcriptomes as continuous vectors, allowing them to be interleaved with natural‑language instructions and other samples. The model is trained on a large corpus that links experimental measurements to biological knowledge and task supervision, covering 157 task groups and 5.21 million conversations. It outperforms competing models on several held‑out annotation tasks, the GEO‑OmicsQA benchmark, and PerturbQA perturbation‑response prediction, demonstrating the benefit of continuous omics representations over text‑only gene lists.

By Maciej Sypetkowski, {\L}ukasz Smoli\'nski, Remigiusz Kinas, Joanna Krawczyk, Bart{\l}omiej Hofman, Aleksandra Mo\.zwi{\l}{\l}o, Micha{\l} Pikusa, Tomasz Jetka, Rafa{\l} Powalski
arXiv AI
Oct 27

OmicsLM: A Multimodal Large Language Model for Multi-Sample Omics Reasoning

arXiv:2605.06728v2 Announce Type: replace-cross Abstract: Large language models can reason over biological knowledge, but they are not naturally equipped to work with quantitative omics measurements....

By Maciej Sypetkowski, {\L}ukasz Smoli{\'n}ski, Remigiusz Kinas, Joanna Krawczyk, Bart{\l}omiej Hofman, Aleksandra Mo{\.z}wi{\l}{\l}o, Micha{\l} Pikusa, Tomasz Jetka, Rafa{\l} Powalski
arXiv Computation and Language
3d ago

ShiftRAG: Bypassing the Textual Bottleneck via Decoupled Learning and Continuous Soft Tokens

ShiftRAG is a new retrieval‑augmented generation framework that decouples discriminative retrieval learning from autoregressive generation while still using a single LLM backbone. It addresses the textual bottleneck of existing RAG pipelines by projecting retrieval alignments into continuous soft tokens, creating a high‑bandwidth interface that feeds retrieval signals into the generator. The approach also introduces a soft orthogonality objective to reduce rank collapse and layer‑wise relevance dynamics to preserve fine‑grained latent space, resulting in significant improvements in retrieval and question‑answering performance over state‑of‑the‑art baselines.

By Youmin Ko, Jihong Jeong, Hyunjoon Kim
arXiv Computation and Language
Oct 5

BioMol-MQA: A Multi-Modal Question Answering Dataset For LLM Reasoning Over Bio-Molecular Interactions

BioMol-MQA is a new question‑answering dataset focused on polypharmacy that combines a multimodal knowledge graph—containing both text and molecular structure—with challenging questions designed to test large language models’ ability to retrieve and reason over this diverse information. The dataset highlights the limitations of current retrieval‑augmented generation systems, which typically handle only single‑modality text, by demonstrating that existing LLMs perform poorly unless provided with the necessary multimodal background data. This underscores the need for more robust RAG frameworks capable of integrating multiple data types for accurate responses.

By Saptarshi Sengupta, Shuhua Yang, Paul Kwong Yu, Fali Wang, Suhang Wang
arXiv Machine Learning
Sep 21

Semantic Calibration Prevails Where Token Confidence Fails: Benchmarking Long-Form Scientific QA

The paper presents the first large‑scale benchmark for uncertainty quantification (UQ) calibration in long‑form scientific question answering, evaluating four UQ methods on 685,000 responses from up to 20 large language models across seven datasets. It shows that instruction tuning leads to token‑level probability polarization, undermining token‑level uncertainty signals, while reasoning model families differ in how they handle this effect. Only semantic consistency—consistency of the final answer—provides well‑calibrated outputs, demonstrating that semantic calibration remains robust in multi‑step, dependency‑rich reasoning.

By Philip M\"uller, Nicholas Popovi\v{c}, Michael F\"arber, Peter Steinbach