Sample, Align, Synthesize: Graph-Based Response Synthesis with ConGrs
Read the original on arXiv Computation and Language →The Flow has not summarised this story yet — read it at arXiv Computation and Language.
The Flow has not summarised this story yet — read it at arXiv Computation and Language.
Thalamus‑Reasoning is a 9B multimodal large language model that embeds bulk or single‑cell transcriptomes as continuous vectors, allowing them to be interleaved with natural‑language instructions and other samples. The model is trained on a large corpus that links experimental measurements to biological knowledge and task supervision, covering 157 task groups and 5.21 million conversations. It outperforms competing models on several held‑out annotation tasks, the GEO‑OmicsQA benchmark, and PerturbQA perturbation‑response prediction, demonstrating the benefit of continuous omics representations over text‑only gene lists.
arXiv:2606. 00432v1 Announce Type: new Abstract: As retrieval-augmented generation (RAG) systems scale, it becomes increasingly challenging to ensure faithful grounding in external evidence.
arXiv:2605.06728v2 Announce Type: replace-cross Abstract: Large language models can reason over biological knowledge, but they are not naturally equipped to work with quantitative omics measurements....
ShiftRAG is a new retrieval‑augmented generation framework that decouples discriminative retrieval learning from autoregressive generation while still using a single LLM backbone. It addresses the textual bottleneck of existing RAG pipelines by projecting retrieval alignments into continuous soft tokens, creating a high‑bandwidth interface that feeds retrieval signals into the generator. The approach also introduces a soft orthogonality objective to reduce rank collapse and layer‑wise relevance dynamics to preserve fine‑grained latent space, resulting in significant improvements in retrieval and question‑answering performance over state‑of‑the‑art baselines.
BioMol-MQA is a new question‑answering dataset focused on polypharmacy that combines a multimodal knowledge graph—containing both text and molecular structure—with challenging questions designed to test large language models’ ability to retrieve and reason over this diverse information. The dataset highlights the limitations of current retrieval‑augmented generation systems, which typically handle only single‑modality text, by demonstrating that existing LLMs perform poorly unless provided with the necessary multimodal background data. This underscores the need for more robust RAG frameworks capable of integrating multiple data types for accurate responses.
The paper presents the first large‑scale benchmark for uncertainty quantification (UQ) calibration in long‑form scientific question answering, evaluating four UQ methods on 685,000 responses from up to 20 large language models across seven datasets. It shows that instruction tuning leads to token‑level probability polarization, undermining token‑level uncertainty signals, while reasoning model families differ in how they handle this effect. Only semantic consistency—consistency of the final answer—provides well‑calibrated outputs, demonstrating that semantic calibration remains robust in multi‑step, dependency‑rich reasoning.