arXiv:2606. 27174v1 Announce Type: new Abstract: Medical device recalls are a critical regulatory mechanism for protecting patient safety.
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Medical device recalls are a critical regulatory mechanism for protecting patient safety. The growing volume of FDA recall records presents challenges in post-report recall triage, severity assessment, and root-cause interpretation.
arXiv:2606. 19183v1 Announce Type: cross Abstract: Large language models (LLMs) can make clinical decision support more accessible by interpreting free-text documentation, but their direct use as diagnostic engines is limited by sensitivity to prompts, information order, and plausible but incorrect outputs.
The paper presents a decision‑aware framework for predicting dementia‑related crash severity that emphasizes auditability and selective deferral. Using 4,781 Texas crash records, the authors evaluate several models—including structured, narrative, fusion, calibrated fusion, BERT‑family, and local large‑language‑model baselines—under a stratified 70/15/15 split. The leakage‑controlled Gemma model achieves the highest macro‑F1 of 0.545, while a calibrated fusion model reaches 0.522 macro‑F1 with an expected calibration error of 0.033; selective deferral further improves performance, raising macro‑F1 to 0.573 at 70% coverage and reducing severity cost to 0.577.
The paper introduces a unified pre‑training framework for medical representations that incorporates hierarchical sub‑token aggregation, partial masking, and cross‑reference mechanisms to better capture the structure of medical codes. The resulting model outperforms existing BERT‑based approaches on pre‑training tasks and downstream clinical predictions, such as dementia onset and hospitalization. An in‑silico drug repositioning study for Alzheimer’s disease demonstrates the framework’s ability to rediscover known drugs and prioritize new hypotheses without external literature, establishing a workflow for hypothesis generation and prioritization based on observational data.
arXiv:2606. 24102v1 Announce Type: cross Abstract: Most electronic health record (EHR) foundation models encode clinical events as discrete event tokens from a fixed vocabulary and therefore cannot directly represent events containing unseen concepts or new combinations of concepts and attributes such as numeric values.
arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.