arXiv AI By Yuxiang Wang, Baojian Zhou, Qifang Zhao, Keyue Jiang, Yanghua Xiao, Xiaoxiao Xu

ProtAgent: Post-Training Compact Protein Tool Agents with Interaction-Level Credit Assignment

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arXiv Machine Learning
Sep 22

Tool-Augmented On-Policy Distillation for LLM Domain Adaptation in Sequence-Based Omics Tasks

The paper introduces OmicsBench, a new reasoning benchmark for multi‑omics sequences that includes 1,160 expert‑validated questions across DNA regulation, RNA processing, and protein function tasks, requiring traceable evidence chains. Evaluation of 17 large language models shows that scientific LLMs, while more accurate in classification, often lack valid evidence, suggesting shortcut learning. To address this, the authors propose tool‑augmented on‑policy distillation (TA‑OPD), a post‑training method that improves both evidence grounding and predictive performance across five Qwen3.5 models of varying sizes.

By Jie Ying, Zhefan Wang, Zihong Chen, Zhengqing Li, Jinzhe Li, Gang Li, Jian Liu, Fang Hu, Tao Luo, Zhonghang Yuan, Wanli Ouyang, Stan Z. Li, Fan Yang, Nanqing Dong
arXiv AI
Sep 3

UniToolCall: Unifying Tool-Use Representation, Data, and Evaluation for LLM Agents

UniToolCall introduces a unified framework for tool-use in large language model agents, standardizing toolset construction, dataset generation, and evaluation. The framework aggregates over 22,000 tools and creates a hybrid training corpus of more than 390,000 instances by combining ten public datasets with synthetically generated, structurally controlled trajectories. It models diverse interaction patterns—single‑hop vs. multi‑hop, single‑turn vs. multi‑turn, serial vs. parallel execution—and adds an Anchor Linkage mechanism to enforce cross‑turn dependencies, while converting seven public benchmarks into a common Query–Action–Observation–Answer format for fine‑grained evaluation.

By Yijuan Liang, Xinghao Chen, Yifan Ge, Ziyi Wu, Hao Wu, Changyu Zeng, Wei Xing, Xiaoyu Shen