Pheno-GS: Phenoscape-scale Geodesic Sinkhorn

Pheno-GS is a new method for computing scalable, geometry-aware optimal transport distances between large patient cohorts of single‑cell data. It uses graph connectivity regularization, an unbalanced OT formulation with KL marginal penalties, and a batched matrix algorithm that dramatically speeds up pairwise distance calculations. The authors validate the approach on synthetic benchmarks and a CyTOF perturbation dataset.

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• rag
• diffusion
• efficiency
• benchmarks