arXiv Machine Learning By Genoria AI Team, Yuejie Hou, Yueyuxiao Yang, Weiting Tang, Meng Yang

Operon-S1: a fast decision controller for long-horizon biomedical agents

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Operon‑S1 is a fast decision controller that separates a language‑model agent’s judgment from its execution, posing 13 closed questions at key decision points and using a lightweight decision model to answer them. In seven life‑science benchmarks, the local decision model handled judgments in 0.6 s on median with no measurable impact on agent performance, while the main language model’s involvement accounted for 8–35 % of task cost. The system records every decision and its outcome, allowing retraining to improve accuracy, and is already applied to wet‑lab protocol troubleshooting and germline panel design.

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