arXiv AI By Gideon Shaked, Siddharth Nagisetty

OmicsBench: a long-horizon multi-turn benchmark of AI agents on research-study-scale bioinformatics

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OmicsBench is a new long‑horizon, multi‑turn bioinformatics benchmark for AI agents, comprising 97 tasks that link 662 subtasks into directed acyclic graphs. Each subtask is a user turn scored deterministically, with optional in‑context feedback. Across 12 models, agents achieve mean scores between 0.43 and 0.67, revealing lower performance on dependent subtasks and highlighting qualitative failure modes through an unsupervised discovery pipeline.

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