arXiv:2610.07913v1 Announce Type: cross
Abstract: Gastric adenocarcinoma (GA) is a leading cause of cancer-related mortality worldwide, and accurate histopathological subtype classification from whol...
By Shrihari Dumbre, Bikash Santra
MIST is a multimodal survival prediction framework that fuses whole-slide images and genomic profiles by representing genomic features as tokens that query histology context tokens derived from a foundation model. The architecture enriches molecular information with histology context before survival prediction, avoiding late-stage merging of separately encoded modalities. Training incorporates discrete-time survival prediction, genomic feature masking, WSI dropout, and contrastive alignment, and demonstrates improved external C-index across colon, renal, lung, and glioblastoma cohorts compared to standard fusion baselines.
By Muhammet Sami Yavuz, Sabri Mustafa Kahya, Richard R. Chen, Jana Lipkova, Benedikt Wiestler
The study introduces a computationally efficient multi‑section whole slide image analysis framework that captures the entire prostate tumor landscape to predict biochemical recurrence (BCR) after radical prostatectomy. Using a large dataset of 23,451 slides from 789 patients, the authors optimized patch and slide subsampling to reduce computational demands while achieving strong predictive performance for 1‑ and 2‑year BCR, comparable to or better than existing clinical benchmarks. The AI‑derived risk score was an independent prognostic factor, improved prognostic performance when combined with clinical variables, and showed preliminary transferability in an external cohort, with attention‑dispersion analysis confirming that the model leveraged information from multiple sections consistent with prostate cancer’s multifocal nature.
By Yesung Cho, Dongmyung Shin, Sujeong Hong, Jooyeon Lee, Seongmin Park, Geongyu Lee, Won Young Park, Bongjin Park, Jongbae Park, Hong Koo Ha
arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.
By Jingyu Hu, Giuseppe Tripodi, Reed Naidoo, Sarah F. McGough, Tapabrata Chakraborti
Multimodal fusion learning (MFL) has shown great potential in the medical domain, where we are faced with disparate data modalities such as imaging, clinical records, and omics. However, existing MFL strategies face several major challenges.
The paper introduces GPF‑Net, a Gated Progressive Fusion Network designed for colonoscopic polyp re‑identification. It fuses multimodal features from multiple levels using fully connected gating mechanisms, allowing layer‑wise refinement of semantic information. Experiments on standard benchmarks show that this multimodal, progressive fusion approach outperforms state‑of‑the‑art unimodal ReID models, especially for small polyps where fine‑grained details are crucial.
By Suncheng Xiang, Xiaoyang Wang, Junjie Jiang, Hejia Wang, Dahong Qian