arXiv Computer Vision By Qiming He, Jing Li, Zihan Wang, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yexing Zhang, Yizhi Wang, Xinrui Chen, Xitong Ling, Minxi Ouyang, Yujie Xie, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Qiang Huang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Chao He, Yonghong He, Zhe Wang

Knowledge-structured and evidence-aware semantic self-distillation for glomerular pathology foundation model

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The paper introduces GloSAGE, a semantic self‑distillation framework that leverages lesion profiles from a pretrained visual teacher to generate structured pathology descriptions for glomerular images. By selecting reliable image‑text anchors and synthesizing knowledge‑structured text, GloSAGE trains a frozen visual encoder with an intermediate semantic transfer layer, enabling zero‑shot lesion recognition, image‑text retrieval, and improved downstream tasks such as disease classification and renal function estimation. Experiments on the GloMillion dataset and seven cohorts demonstrate that GloSAGE outperforms its source visual model in most lesion‑recognition tasks and enhances grading accuracy while maintaining competitive performance on case‑level analyses.

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