arXiv Machine Learning By Calvin McCarter, Nick Bhattacharya, Sebastian W. Ober, Hunter Elliott

How to make the most of your masked language model for protein engineering

Read the original on arXiv Machine Learning →

arXiv:2603. 10302v3 Announce Type: replace Abstract: A plethora of protein language models have been released in recent years.

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Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progress in single-chain protein modeling and generation, they often fall short in antigen-specific antibody design, where effective modeling requires explicit pairing between antibody and antigen, particularly at the epitope level.