Dynamic Generalized Gromov-Wasserstein Optimal Transport extends classical optimal transport by incorporating structure-aware transport costs, which is especially relevant for spatial transcriptomics where preserving tissue structure is crucial. The paper introduces TP-DATE, a simulation-free framework that generalizes GW-OT dynamically, formulating static and dynamic Quadratic-form OT through path actions and proving their equivalence. TP-DATE employs travelling-pair flow matching to enable interacting conditional paths, resulting in better preservation of spatial structure and improved continuous 3D dynamics reconstruction on both synthetic and real spatial transcriptomics data.
arXiv:2608. 15306v1 Announce Type: cross Abstract: High-throughput single-cell and spatial transcriptomic technologies provide high-resolution snapshots of heterogeneous cellular states, but their destructive nature prevents repeated measurements of the same cells over time.
By Mary Chriselda Antony Oliver, Kaitlyn Hohmeier, Tuyen Tran, Alejandra Castillo, Caroline Moosm\"uller, Shiying Li
arXiv:2510. 01894v3 Announce Type: replace Abstract: Many natural dynamic processes -- such as in vivo cellular differentiation or disease progression -- can only be observed through the lens of static sample snapshots.
By Thomas Gravier, Thomas Boyer, Auguste Genovesio
arXiv:2608.21070v1 Announce Type: cross
Abstract: Inferring continuous system evolution from sparse temporal snapshots is a key challenge in generative modeling and single-cell omics. While Optimal T...
By Yuhao Sun, Zekun Wu, Zixun Huang, Peijie Zhou
arXiv:2607. 04738v1 Announce Type: cross Abstract: Reconstructing population dynamics is a central problem in the physical and data sciences.
By Markus Heinonen, Yair Shenfeld, Ricardo Baptista, Daniel Waxman, Dmitry Batenkov, Tim Cooijmans, Eli Bingham
Reconstructing population dynamics is a central problem in the physical and data sciences. Often, the dynamics are modeled as a Wasserstein gradient flow (WGF): a curve of distributions driven by an energy functional.