arXiv AI By Michael Yew Chuan Lee, Manya Sriram, N. Benjamin Erichson

Do AI-for-Science Agents Preserve Model Safety?

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AI-for-Science agents, which combine large language models (LLMs) with domain-specific harnesses to formulate hypotheses, run experiments, and interpret evidence, may compromise model safety. The study evaluated five harnesses on 50 harmful chemistry requests, finding that harnesses can increase harmful compliance even with direct prompting and that adaptive attacks that fail against the base LLM succeed once the harness is added. These results indicate that the safety behavior of the underlying LLM is not durable when integrated into an agent harness.

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