Causal inference using front door intervention and multi-instance learning (MIL) has advanced the analysis of Whole Slide Images (WSI) in digital pathology. These methods adjust feature distributions of subtle evidence sub-images to correctly associate them with WSI-level diagnoses.
arXiv:2502.02707v5 Announce Type: replace
Abstract: Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervis...
By Shuyang Wu, Yifu Qiu, Ines P. Nearchou, Sandrine Prost, Jonathan A. Fallowfield, Hideki Ueno, Hitoshi Tsuda, David J. Harrison, Hakan Bilen, Timothy J. Kendall
arXiv:2606. 06864v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become a standard paradigm for whole slide image (WSI) analysis in digital pathology, as it enables slide-level prediction without dense annotations.
By Yonghan Shin, Won-Ki Jeong
arXiv:2610.15669v2 Announce Type: replace-cross
Abstract: Weak bag-level labels are widely available in computational pathology, whereas reliable instance-level annotations for whole-slide images rem...
By Chen Shu, Chengyang Zhang, Boyu Fu, Ting Yin, Wenchuan Zhang, Jie Chen, Yuhao Yi, Hong Bu
arXiv:2609.00396v1 Announce Type: new
Abstract: Histopathological whole slide images (WSIs) are central to cancer diagnosis, but their gigapixel scale, tissue heterogeneity, weak slide-level supervis...
By Chad Wong, Sicheng Chen, Tianyi Zhang, Enhui Chai, Yueming Jin, Zeyu Liu, Fei Xia
The paper presents a plug‑and‑play framework that uses concept-based interpretation to debug medical imaging models. By aligning a single‑modality encoder with BioMedCLIP, the authors build a Concept Bottleneck Model that allows concept‑level interventions to distinguish causal from spurious features. Experiments on Mayo Clinic ultrasound and CheXpert chest X‑ray data show that these interventions can reliably diagnose model issues and even improve performance through guided fine‑tuning.
By Samrajya Thapa, Daniel J. Quest, Timothy L. Kline, Carrie L. Langstraat, Emanuel C. Trabuco, Wei Le