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Coupled Tensor-Tensor Completion Method with Applications in Drug Repurposing

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The paper introduces Coupled Tensor‑Tensor Completion (CTTC), a new framework that incorporates side information in tensor form to enhance tensor completion tasks. CTTC leverages hidden connections among multimodal tensors and is grounded in distance metric learning and group theory. Experiments on the DTD and LINCS datasets show that CTTC outperforms existing methods such as HaLRTC, CTRC, Cell, and NTDDR in both run‑time and root‑sum‑of‑errors accuracy for predicting drug effects.

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