arXiv AI By Qingyuan Zeng, Ziyang Chen, Pengxiang Cai, Zixin Guan, Anglin Liu, Lang Qin, Xinyao Lai, Jintai Chen

Can Broad Biomedical Knowledge be Contextualized into Scenario-Grounded Propositions?

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The paper introduces SCENE, a bi-level multi-agent framework that transforms broad biomedical knowledge into scenario‑grounded propositions. SCENE operates by iteratively converting general knowledge into dataset‑specific search directions and then optimizing for propositions that balance evidential strength and data support. The method is evaluated on clinical trial subgroups and LINCS L1000 perturbation studies, outperforming baselines and yielding traceable, inspectable hypotheses.

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