Advancing Interaction-Sensitive Feature Selection: Novel Relief-Based Algorithms, Expanded Comparisons, and Recommendations for Biomedical Data Mining
Read the original on arXiv Machine Learning →The paper refactors and expands the scikit-rebate Python package, adding new Relief‑Based Algorithm (RBA) variants such as SWRF*, mu‑Relief, and five novel methods that use alternative neighbor selection and feature scoring strategies. Benchmarking across diverse genomic simulations shows that most RBAs, except mu‑Relief, effectively detect 2‑way interactions in noisy data, with far‑scoring variants like MultiSWRFDB* excelling at interaction detection but being less sensitive to main effects. The refactored package achieves 10‑ to 35‑fold runtime reductions, and the new RBAs maintain strong performance for both main effects and 2‑way epistatic interactions, preserving predictive signals for downstream modeling.
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