arXiv:2608. 07796v1 Announce Type: new Abstract: Large language models perform strongly on medical knowledge benchmarks, but reliable clinical deployment requires agents to conduct defensible investigations over heterogeneous, longitudinal records: determining what evidence is needed, retrieving and reconciling structured and free-text data, grounding conclusions in verifiable evidence, and deferring cases that cannot be resolved reliably.
By Veronica Chatrath, Bryan Zhu, George Pu, Jingxuan Fan, Apaar Shanker, Varun Ursekar, Anahita Sharma, Jason Qin, Keqi Han, Soham Dinesh Tiwari, Soham Dan, Vijay Kalmath, Yuan Li, Daniel Yue Zhang, Chenguang Wang, Zainab Doctor, Zhijun Yin, Nigam H. Shah, Yuan Xue
arXiv:2607. 12480v1 Announce Type: new Abstract: This paper defines TRACE (Typed Reasoning And Commitment Evidence): a typed, versioned schema for recording reasoning traces, a reference procedure for writing records against it, and one operating discipline, no durable state change without a record.
By Edward Y. Chang, Emily J. Chang
arXiv:2610.01938v1 Announce Type: cross
Abstract: Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integr...
By Zhangshu Joshua Jiang, Zina Ibrahim, James T. Teo
The article proposes a framework called quantitative evidence mining to transform biomedical findings into structured, context-rich evidence units. It outlines core elements such as claim, measured entity, value, comparator, population, conditions, temporal context, uncertainty, provenance, validation, and expert review. The authors present an eight-stage reference architecture and emphasize that plausibility should remain multidimensional rather than collapsed into a single truth label, linking extraction to evidence synthesis for applications like clinical trials, biomarker research, and knowledge-graph construction.
By Negin Sadat Babaiha, Stefan Geissler, Marie-Christine Simon, Martin Hofmann-Apitius, Marc Jacobs
arXiv:2608.30393v1 Announce Type: new
Abstract: Biomedical artificial intelligence (AI) systems increasingly extract, organize, and reuse scientific claims from literature, clinical trials, and regul...
By Negin Sadat Babaiha, Stefan Geissler, Marie-Christine Simon, Martin Hofmann-Apitius, Marc Jacobs
The paper introduces AGVF, a multi‑agent framework for generating medical‑necessity appeals that must adhere to payer policy and evidence constraints. AGVF treats appeal synthesis as a Constrained Markov Decision Process involving five agents—policy formalization, evidence retrieval, gap analysis, adversarial critique, and gated synthesis—and proves that refining the policy constraint graph monotonically reduces evidence deficiency. A deterministic citation‑grounding gate ensures no unsupported assertions enter the shared state, and validation on 1,000 synthetic cases shows zero citation violations and monotonic deficiency reduction.
By Harshil Lodhiya, Alex McManus, Reese Walker
arXiv:2601.12547v2 Announce Type: replace
Abstract: Clinical artificial intelligence increasingly builds high-dimensional representations of patients, yet every finite clinical model is an abstractio...
By Dipayan Sengupta, Saumya Panda
The paper introduces a source‑grounded integrity gate for AI‑assisted personal health records, ensuring that data generated by large language models remains provisional until a deterministic monitor verifies it against the source document. The monitor only accepts candidates that contain a unique supporting quotation, appear within the same laboratory row, and preserve provenance, preventing the model from approving its own output. In Medical DataCloud, the system passed all 22 conformance and mutation tests and, in a replay of nine historical lab reports, admitted 72 of 97 numeric candidates while retaining 25 for human review.
By Nora Girda, Adrian Groza
The paper introduces Positive Topology, a framework built on a basic relation between points (or models) and observable properties. It identifies two complementary structures: universal refinement and cover, and positivity and witnessed existence, showing that each can reconstruct the underlying relation. The authors present both information‑theoretic and game‑theoretic interpretations, and discuss how resource constraints can be integrated, illustrating applications in medical diagnosis, legal reasoning, and AI.
By Mirco A. Mannucci, Giovanni Sambin
arXiv:2606. 31273v1 Announce Type: new Abstract: AI-assisted research has entered a stage in which the central question is not only whether systems can generate hypotheses, run experiments, or produce manuscripts, but whether their scientific claims are calibrated to the evidence that supports them.
By Hongmin Li
EviDx is a new framework for evidence-aware active diagnosis that pairs patient-specific diagnostic environments with a clinical scaffold and an observer-guided runtime harness. The framework constructs interactive environments from raw clinical cases, organizes role-specialized agents and evidence tools, and regulates diagnostic termination by tracking uncertainty and evidence coverage. Experiments demonstrate that EviDx improves diagnostic performance and process stability while revealing model-dependent capability boundaries.
By Lihang Zeng, Shaoting Zhang, Xiaofan Zhang
arXiv:2609.05531v1 Announce Type: cross
Abstract: No specification says how a governed autotelic AI agent organization, where agents pursue self-generated goals inside guardrails, should be designed...
By Michael Ray Johnson, Linda Naimi