arXiv:2411. 05196v3 Announce Type: replace Abstract: This study presents DhondtXAI as a SHAP-independent, D'Hondt-based attribution framework for tabular XAI.
arXiv:2609.14902v1 Announce Type: cross Abstract: Shapley value (SV)-based methods are the prevailing framework for feature attribution in machine learning, yet existing population-level Shapley esti...
arXiv:2605. 12895v2 Announce Type: replace-cross Abstract: Clinical decision-support systems are expert systems whose recommendations clinicians act on directly, yet they are usually cleared on one aggregate accuracy number from a held-out test set.
The study evaluates a standalone large language model (LLM) versus a four‑step agentic pipeline for generating explanations of ICU mortality predictions on the eICU Demo dataset. XGBoost achieved an AUROC of 0.855 and an AUPRC of 0.332. In a 38‑case explanation subset, the standalone LLM produced one explanation with outcome leakage, while the agentic pipeline produced none; among 14 overlapping SHAP cases, the standalone LLM had higher SHAP alignment and direction consistency, whereas the agentic pipeline showed better guideline grounding, value specificity, and plausibility.
arXiv:2607. 24878v1 Announce Type: cross Abstract: Phenotype-driven diagnostic benchmarks usually report the rank of the reference disease, but they rarely reveal which plausible alternatives are ranked above it or what evidence a tool-using model examines before making its decision.
arXiv:2606. 14823v1 Announce Type: cross Abstract: Genetic evidence is enriched among approved drug targets: in an observational analysis of 26,278 target-disease pairs from Open Targets and ChEMBL, targets with any genetic association had a 3.
arXiv:2601. 05151v3 Announce Type: replace-cross Abstract: Feature selection (FS) is essential for biomarker discovery and clinical predictive modeling.
Background: Disease severity is a multidimensional construct difficult to capture with rule-based approaches in Electronic Healthcare Records (EHR). Agentic large language model (LLM) systems could synthesise clinical evidence and reason over EHRs, but remain unevaluated for this task.
The paper introduces FCA‑Guided Counterfactual (FCA‑CF) explanations for multi‑modal breast cancer diagnosis, leveraging a Formal Concept Analysis lattice as a hard structural constraint to search for counterfactuals. On the TCGA‑BRCA dataset, FCA‑CF achieves perfect validity (100% prediction flips), the lowest average feature changes (2.37), and competitive proximity (0.900) compared to four other methods. Ablation studies show the lattice constraint drives sparsity, while a greedy refinement phase further improves results.
arXiv:2607. 17345v1 Announce Type: new Abstract: Background: Untargeted LC-MS metabolomics requires a long chain of preprocessing decisions, each with several equally defensible options.
The paper introduces FCA‑Guided Counterfactual (FCA‑CF) explanations for multi‑modal breast cancer diagnosis, leveraging a Formal Concept Analysis lattice as a hard structural constraint to generate counterfactuals. On the TCGA‑BRCA dataset, FCA‑CF achieves perfect validity (100% prediction flips), the lowest average feature changes (2.37), and competitive proximity (0.900), outperforming four established counterfactual methods. Ablation studies show the lattice constraint and a greedy refinement phase are key to its sparsity and validity.
arXiv:2609. 22154v1 Announce Type: new Abstract: Tabular data is the most common format in clinical practice, encompassing laboratory results, medication records, diagnostic codes, and patient demographics.
The study evaluates whether a portfolio of compact, semantically named descriptor blocks can match the performance of a 2048‑dimensional CheMeleon embedding in low‑data molecular assays. Using a fixed 11‑dimensional physicochemical base and greedily adding provenance‑screened blocks, the portfolio achieves a mean test AUC of 0.762 across nine ADME/Tox assays, comparable to CheMeleon’s 0.764 and better than Mordred’s 0.756. The results meet a predeclared pooled parity threshold but not all per‑assay thresholds, and further analysis confirms the competitiveness of the auditable representation while highlighting unresolved assay‑level differences.