arXiv Machine Learning

DPsurv: Dual-Prototype Evidential Fusion for Uncertainty-Aware and Interpretable Whole-Slide Image Survival Prediction

arXiv:2510. 00053v2 Announce Type: replace-cross Abstract: Pathology whole-slide images (WSIs) are widely used for cancer survival analysis because of their comprehensive histopathological information at both cellular and tissue levels, enabling quantitative, large-scale, and prognostically rich tumor feature analysis.

arXiv Machine Learning
Sep 23

Evidential Fusion Network for Multimodal Survival Prediction under Missing Modalities

The paper introduces the Evidential Missing Modality Survival Fusion (EMMS) model, which predicts survival outcomes using multimodal data even when some modalities are missing. EMMS applies Dempster‑Shafer theory and Gaussian Random Fuzzy Numbers to fuse information, accounting for both aleatoric and epistemic uncertainty and the reliability of each modality. Experiments on four cancer datasets show that EMMS achieves state‑of‑the‑art performance while providing calibrated, interpretable uncertainty estimates without extra computational cost.

By Yucheng Xing, Hailan Mo, Zi Wang, Ling Huang, Mengling Feng
arXiv AI
Sep 1

Towards Accurate and Lightweight Peripheral Neuroblastic Tumor Diagnosis via Contrastive Multi-scale Pathological Image Analysis

The paper introduces CoPath, a lightweight framework for diagnosing peripheral neuroblastic tumors (pNTs) from whole-slide images. CoPath combines CoHisNet, a multi‑scale feature‑fusion network that replaces traditional MLPs with Kolmogorov‑Arnold Network layers for efficient nonlinear modeling, and PathVote, which aggregates patch‑level predictions using pathology‑informed priors. Experiments on a private pNT cohort and the public BreakHis dataset show that CoPath matches or surpasses existing classifiers while reducing computational complexity.

By Zhu Zhu, Shuo Jiang, Jingyuan Zheng, Yawen Li, Yifei Chen, Manli Zhao, Weizhong Gu, Feiwei Qin, Jinhu Wang, Gang Yu
arXiv Machine Learning
Sep 3

Morphology signal in whole slide image foundation models can automatically triage slides

The paper introduces a pipeline that uses publicly available whole slide image foundation models (FMs) to automatically triage slides by ranking them based on zero‑shot classification predictions. This approach accurately identifies slides containing the most tumor, achieving top‑2 ranking for patients with up to 43 slides across multiple datasets. The study also proposes a ranked evaluation framework to benchmark FM performance in slide triage.

By Ayushi Sinha, Shashank Yadav, Benjamin Holmes, Pravat Das, Aaron W. Bogan, James S. Lewis Jr., Santiago Romero-Brufau, Andrew Y. K. Foong, Scott H. Kaufmann, Kathryn M. Van Abel, David M. Routman, Michael R. Lucas
arXiv Computer Vision
Sep 11

PathoHR: Breast Cancer Survival Prediction on High-Resolution Pathological Images

PathoHR is a new pipeline for predicting breast cancer survival from high‑resolution pathological images. It uses a plug‑and‑play Vision Transformer to enhance patch‑wise whole slide image representations, evaluates multiple similarity metrics to optimize feature learning, and shows that smaller, enhanced patches can match or surpass the accuracy of larger raw patches while cutting computational cost. The authors provide experimental evidence that this approach improves both accuracy and efficiency in computational pathology.

By Yang Luo, Shiru Wang, Jun Liu, Jiaxuan Xiao, Rundong Xue, Zeyu Zhang, Hao Zhang, Yu Lu, Yang Zhao, Yutong Xie
arXiv AI
Jun 17

Probing, Fusion, and Trustworthiness: A Systematic Evaluation of Foundation Model Representations for Multimodal Cancer Analysis

arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.

By Jingyu Hu, Giuseppe Tripodi, Reed Naidoo, Sarah F. McGough, Tapabrata Chakraborti
arXiv AI
Jun 8

DaX: Learning General Pathology Representations Across Scales

arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.

By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
arXiv AI
Sep 21

MIST: Multimodal Survival Prediction with Genomic-Guided Histology Attention

MIST is a multimodal survival prediction framework that fuses whole-slide images and genomic profiles by representing genomic features as tokens that query histology context tokens derived from a foundation model. The architecture enriches molecular information with histology context before survival prediction, avoiding late-stage merging of separately encoded modalities. Training incorporates discrete-time survival prediction, genomic feature masking, WSI dropout, and contrastive alignment, and demonstrates improved external C-index across colon, renal, lung, and glioblastoma cohorts compared to standard fusion baselines.

By Muhammet Sami Yavuz, Sabri Mustafa Kahya, Richard R. Chen, Jana Lipkova, Benedikt Wiestler