arXiv AI

MedCalc-Pro: Solving Complex Medical Calculations with LLM Agents

arXiv:2607. 02879v1 Announce Type: new Abstract: Current benchmarks for evaluating large language models (LLMs) in medical calculation are largely based on simplified settings, where each patient case corresponds to a single calculator and the required tool is explicitly specified in the query.

arXiv AI
Jul 22

MEDIC: Comprehensive Evaluation of Leading Indicators for LLM Safety and Utility in Clinical Applications

arXiv:2409. 07314v3 Announce Type: replace-cross Abstract: While Large Language Models (LLMs) achieve superhuman performance on standardized medical licensing exams, these static benchmarks have become saturated and increasingly disconnected from the functional requirements of clinical workflows.

By Praveenkumar Kanithi, Cl\'ement Christophe, Marco AF Pimentel, Tathagata Raha, Prateek Munjal, Nada Saadi, Hamza A Javed, Svetlana Maslenkova, Nasir Hayat, Ronnie Rajan, Shadab Khan
arXiv Computation and Language
Aug 27

Retrieval-Augmented Agentic Rubric Generation for Reliable Medical Response Evaluation

The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.

By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv AI
Aug 18

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

arXiv:2505. 14107v5 Announce Type: replace-cross Abstract: The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios.

By Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang
arXiv Computation and Language
Sep 14

Tasks over Application Manuals: Revealing Gaps in Long-Horizon Procedural Reasoning for Language Models

The paper introduces Tasks over Application Manuals (TAM), a benchmark designed to test long‑horizon procedural reasoning in large language models. TAM uses real‑world tasks from ICD‑10‑CM clinical coding and U.S. federal sentencing, requiring models to follow extensive, rule‑based manuals and perform interdependent steps to produce exact answers. Experiments with GPT‑5 and various prompting strategies show very low exact‑match accuracy—1% for coding and 15.5% for sentencing—highlighting a gap between current benchmarks and the ability to reliably follow complex procedures.

By Utkarsh Soni, Syed Shariyar Murtaza, Yifan Nie, Sachin Chandrasekhar, Eugene Wen
arXiv AI
Sep 12

Towards a Deterministic Math Solver for Clinical Language Models

The paper explores a new approach to improve arithmetic reliability in clinical language models by having the model generate case‑specific Python code that a local executor runs deterministically, rather than performing arithmetic directly. Experiments on the MedCalc‑Bench Verified dataset show that this Program‑Solve interface yields modest gains for larger models (Qwen2.5‑32B) but not for smaller ones (Qwen2.5‑7B), and it does not replace the need for verified formulas or accurate variable extraction. The study highlights that adding an executor can help some open‑weight models but is not a universal solution.

By Felipe Ocampo Osorio, Sebasti\'an Andr\'es Cajas Ordo\~nez, Maximin Lange, Rafi Al Attrach, Sahil Kapadia, Zakaria Laouabdia Sellami, Angelo Antonio Talio, Leo Anthony Celi
arXiv AI
Jun 17

RubricsTree: Scalable and Evolving Open-Ended Evaluation of Personal Health Agents across Health Memory and Medical Skills

arXiv:2606. 18203v1 Announce Type: cross Abstract: The LLM-empowered personal health agents with user health (sensor) metrics have offered a promising pathway to alleviate global disparities in healthcare access.

By Weizhi Zhang, Zechen Li, Hamid Palangi, Ben Graef, A. Ali Heydari, Simon A. Lee, Salman Rahman, Ray Luo, Zeinab Esmaeilpour, Erik Schenck, Chloe Zhang, Yamin Li, Menglian Zhou, Philip S. Yu, Daniel McDuff, Lindsey Sunden, Mark Malhotra, Shwetak Patel, Ahmed A. Metwally
arXiv AI
2d ago

Scaling Clinical Judgment to Evaluate Medical AI

arXiv:2609.12822v2 Announce Type: replace Abstract: Blinded physician evaluation has been considered by many to be the gold standard for assessing clinical reasoning in large language models (LLMs)....

By Thomas A. Buckley, Zahir Kanjee, Peter G. Brodeur, Byron Crowe, Anthony M. Pettinato, Aashna P. Shah, Adrian D. Haimovich, Liam G. McCoy, Daniel Restrepo, Jason A. Freed, Ethan Goh, Jonathan H. Chen, Laura Zwaan, Katherine E. Goodman, Daniel J. Morgan, Raja-Elie E. Abdulnour, Adam Rodman, Arjun K. Manrai
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam