DeepMind Blog

Revealing a key protein behind heart disease

AlphaFold has revealed the structure of a key protein behind heart disease

Towards Data Science
Jun 18

Proteins: A Mosaic Pattern to Rule Them All?

For decades, the existence of the hydrophobic core, a region in the 3D structure of proteins where hydrophobic amino acids reside together, has been considered a general property in proteins. What we have found now may extend that model.

By Francisco Javier Lobo-Cabrera
arXiv Machine Learning
Jul 21

CORAL: Learning Amyloid Fibril Ligand Docking with Cooperative Binding Rewards

arXiv:2607. 17412v1 Announce Type: new Abstract: A hallmark of neurodegenerative diseases such as Alzheimer's and Parkinson's is the aberrant aggregation of proteins into amyloid fibrils, and small molecules that selectively bind to these fibrils hold promise as diagnostics, imaging probes, and therapeutics.

By Yasheng Sun, Bohan Li, Youqi Tao, J\"urgen Schmidhuber
arXiv Machine Learning
Jun 29

PairSAE: Mechanistic Interpretability from Pair Representations in Protein Co-Folding

arXiv:2606. 27440v1 Announce Type: new Abstract: Foundation models for structural biology have achieved remarkable performance in predicting biomolecular structure and show promise for the design of proteins and small molecules.

By Giosue Migliorini, Aristofanis Rontogiannis, Grigori Guitchounts, Nicholas Franklin, Axel Elaldi, Olivia Viessmann