arXiv:2607. 12474v1 Announce Type: new Abstract: Recent advances in foundation models have transformed AI for Science, enabling remarkably accurate predictive performance across domains ranging from protein folding to weather forecasting.
By Ingmar Posner, Anson Lei, Bernhard Sch\"olkopf
arXiv:2606. 02632v1 Announce Type: cross Abstract: Modern Machine Learning (ML) and Artificial Intelligence (AI) models, especially large language models (LLMs), are increasingly used to generate scientific hypotheses and mechanistic explanations from observational data.
By Tyler H. McCormick
arXiv:2607. 18777v1 Announce Type: new Abstract: Evaluating machine learning in scientific domains requires separating correct predictions from correct reasons under realistic distribution shifts.
By Dongkwan Kim, Yiming Gao, Yining Yang, Yang Shen
arXiv:2606. 06533v1 Announce Type: new Abstract: What would it mean to have a scientific understanding of AI?
By Stella Biderman, Mohammad Aflah Khan, Niloofar Mireshghallah, Catherine Arnett, Fazl Barez, Naomi Saphra
arXiv:2608.30165v1 Announce Type: cross
Abstract: Scientific progress depends not only on finding solutions, but on learning the rules that explain why they work and using that understanding to desig...
By Arya S. Rao, Rodrigo I. Castro, Sager J. Gosai, Kenneth B. Hsu, Yasha Ektefaie, Shantanu Singh, Sangeeta N. Bhatia, Steven K. Reilly, Ryan Tewhey, Eric S. Lander, Pardis C. Sabeti
The paper introduces SAEScientist-Bench, a benchmark that tests whether AI agents can autonomously conduct mechanistic interpretability research using Sparse Autoencoders (SAEs). Agents are tasked with designing contrastive probes and navigating a large feature dictionary in Gemma-2-9B-IT to identify optimal features for a target concept, with performance measured against expert-curated references on activation rank, concept selectivity, and causal steering. Results show that while frontier agents can discover features and outperform controls, they still lag behind expert baselines, especially in causal steering, highlighting both the potential and current limitations of closed-loop autonomous AI research.
By Yuqiao Tan, Shizhu He, Jun Zhao, Kang Liu
The paper introduces ScientistTwo, a fully autonomous multi‑agent framework that takes a scientific problem, establishes baselines, generates hypotheses, and coordinates specialized agents to conduct an end‑to‑end discovery cycle without human intervention. It rigorously tests and refines its methods through automated experiments, ablation studies, and a closed‑loop peer‑review engine. Benchmarking against top conferences (ICLR, ICML, NeurIPS) shows that ScientistTwo produces expert‑level, publishable papers and codebases that outperform human state‑of‑the‑art models and receive higher review ratings under automated AI review.
By Jaehyun Nam, Jinsung Yoon, Yanzhou Pan, Yubo Wang, Rui Meng, Parthasarathy Ranganathan, Tomas Pfister
arXiv:2601. 21996v2 Announce Type: replace-cross Abstract: While Mechanistic Interpretability has identified interpretable circuits in LLMs, their causal origins in training data remain elusive.
By Jianhui Chen, Yuzhang Luo, Liangming Pan
arXiv:2609.16213v1 Announce Type: new
Abstract: Artificial intelligence is reshaping biological research across an increasingly connected digital-to-physical workflow. General-purpose large language...
By Candace S. Y. Chan, Aris Karatzikos, Ilias Georgakopoulos-Soares
Predicting the answer to interventional ``what if'' questions --- the outcome of an action never taken --- requires a \emph{mechanistic}, causal model, not a curve fit; and learning such a model requires \emph{experiments}, because passive data leaves its mechanisms unidentified. Experiments are expensive, so the central problem is \emph{data efficiency}.
arXiv:2607. 09195v1 Announce Type: new Abstract: Large language model (LLM) agents are increasingly expected to play a central role in AI-driven scientific discovery.
By Izumi Takahara, Teruyasu Mizoguchi
arXiv:2606. 08532v5 Announce Type: replace Abstract: Modern artificial intelligence excels at prediction but cannot explain.
By Lei Lin, Xinlong Pan, Ronghao Wang, Chunbao Zhou, Jue Wang, Yangang Wang, Ivana Rasovska