arXiv AI

Let Large Language Models Judge Each Other: Multi-Agent Peer-Reviewed Reasoning for Medical Question Answering

The paper introduces a multi-agent peer‑reviewed reasoning approach for medical question answering, where several large language models independently generate chain‑of‑thought explanations and then evaluate each other’s reasoning for factual correctness and logical soundness. The highest‑rated reasoning chain is used to produce the final answer. Experiments with five state‑of‑the‑art LLMs on three benchmark datasets show that this method consistently outperforms single‑model chain‑of‑thought reasoning and majority voting ensembles, achieving an average accuracy of 0.820 versus 0.777 for the best single model.

arXiv AI
Aug 20

Adaptive Memory and Reflection Multi-Agent System for Medical Question Answering

The paper introduces an adaptive memory and reflection (AMR) multi‑agent system for medical question answering. Each agent has dedicated memory and uses reflection‑based feedback to retrieve relevant prior cases, improving reasoning. The system routes questions through solo, collaborative, or escalated workflows and includes consensus and ethical overseer modules, achieving strong performance on MedQA and MedMCQA datasets.

By Pradeep Murugesan, Luoxiao Yang, Xueli Chen, Xinqi Fan
arXiv AI
Sep 4

Medical Reasoning in the Era of LLMs: A Systematic Review of Enhancement Techniques and Applications

The paper reviews how Large Language Models (LLMs) are being adapted for medical reasoning, moving beyond single-step answers to systems that can systematically, transparently, and verifiably reason. It introduces a taxonomy of enhancement techniques, split into training-time methods such as supervised fine‑tuning and reinforcement learning, and test-time methods like prompt engineering and multi‑agent systems. The review examines their application across text, image, and code modalities in key clinical areas—diagnosis, education, and treatment planning—and tracks the shift in evaluation benchmarks from simple accuracy to more nuanced assessments of reasoning quality and visual interpretability.

By Zizhan Ma, Wenxuan Wang, Meidan Ding, Shiyi Zheng, Shengyuan Liu, Jie Liu, Jiaming Ji, Linlin Shen, Yixuan Yuan, Wenting Chen
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv AI
Jun 9

From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG

arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.

By Wenhao Wu, Zhentao Tang, Yafu Li, Shixiong Kai, Mingxuan Yuan, Zhenhong Sun, Chunlin Chen, Zhi Wang
arXiv AI
Jun 17

MedicalAgentsBench for Complex Medical Reasoning: Comparing Internalized Reasoning Models versus Externalized Agent-based Frameworks

arXiv:2503. 07459v3 Announce Type: replace-cross Abstract: Complex medical reasoning requires integrating heterogeneous clinical evidence across multiple inference steps.

By Yanjun Shao, Xiangru Tang, Jiwoong Sohn, Jiapeng Chen, Yuxuan Liao, Jiayi Zhang, Jinyu Xiang, Fang Wu, Yilun Zhao, Chenglin Wu, Wenqi Shi, Arman Cohan, Mark Gerstein
arXiv AI
Sep 1

Scoring, Reasoning, and Selecting the Best! Ensembling Large Language Models via a Peer-Review Process

The paper introduces LLM‑PeerReview, an unsupervised ensemble method that selects the best response from multiple LLM-generated candidates by scoring each answer with several LLMs, aggregating those scores via averaging or a graphical model, and choosing the highest-scoring response. The approach is peer‑review inspired, transparent, and interpretable, and it outperforms the Smoothie‑Global model by 6.9%–7.3% across factual recall QA, math reasoning, and instruction‑following tasks. The authors also provide a curated benchmark suite of 12 ensemble methods evaluated on four datasets and three task families to aid reproducibility.

By Zhijun Chen, Zeyu Ji, Qianren Mao, Hao Wu, Jinhuan Song, Junhang Cheng, Bangjie Qin, Zhuoran Li, Jingzheng Li, Kai Sun, Zizhe Wang, Yikun Ban, Zhu Sun, Xiangyang Ji, Hailong Sun, Xiao Huang
arXiv AI
Oct 2

Scaling Clinical Judgment to Evaluate Medical AI

The paper introduces PrecepTron, a 32‑billion‑parameter language model fine‑tuned with low‑rank adaptation to evaluate clinical reasoning in large language models (LLMs) at a physician level. It also releases GRAND‑ROUNDS, a benchmark of 9,217 scored responses from 160 clinicians across seven studies. Using PrecepTron, the authors replicate key findings from major medical AI studies and explore new questions about LLM diagnostic accuracy, demonstrating that fine‑tuned models can provide consistent, scalable physician‑level scoring.

By Thomas A. Buckley, Zahir Kanjee, Peter G. Brodeur, Byron Crowe, Anthony M. Pettinato, Aashna P. Shah, Adrian D. Haimovich, Liam G. McCoy, Daniel Restrepo, Jason A. Freed, Ethan Goh, Jonathan H. Chen, Laura Zwaan, Katherine E. Goodman, Daniel J. Morgan, Raja-Elie E. Abdulnour, Adam Rodman, Arjun K. Manrai