arXiv:2605. 26833v2 Announce Type: replace-cross Abstract: Polymers underpin applications across energy, healthcare, and materials science, yet their vast chemical space makes systematic discovery challenging.
By Yasharth Yadav, Tze Kwang Gerald Er, Atsushi Goto, Kelin Xia
This paper introduces a new method for predicting transmembrane protein topology by employing the graph neural network SchNet. The model is trained on the same dataset used for DeepTMHMM, using 5‑fold cross‑validation, and incorporates all atom‑level embeddings rather than just sequence or alpha‑carbon features. Results indicate that GNNs hold significant promise for topological predictions without relying on pre‑trained weights.
By Sitong Chen, Xiaopeng Mao
HiPoly is a polymer-native AI framework that uses a three-level hierarchical graph architecture built on the G2RINS representation to process complete polymer descriptions. It encodes stochastic inter-monomer connectivity, composition, and molecular weight directly within its architecture, enabling end-to-end workflows from experimental data to property prediction, generative design, and physics-based validation. The framework achieves state-of-the-art accuracy for thermophysical properties of multi-component polymer systems and demonstrates generative design by discovering sustainable, PFAS-free alternatives with target surface-energy properties.
By Ge Sun, Gervasio Zaldivar, Yuan Tian, Gustavo Perez Lemus, Juhae Park, Dasha Safarian, Ming Han, Juan J. de Pablo
We introduce pVR, a topological machine learning framework for alignment-free genomic sequence classification that combines $p$-adic numbers with topological data analysis. Each DNA sequence is encoded along two complementary axes: a $p$-adic distance on $k$-mer prefixes, which captures hierarchical positional structure, and a compositional $L_1$ distance on $k$-mer frequencies, which captures local sequence content.
arXiv:2606. 06117v1 Announce Type: cross Abstract: We introduce pVR, a topological machine learning framework for alignment-free genomic sequence classification that combines $p$-adic numbers with topological data analysis.
By Tirtharaj Dash, Gunja Sachdeva
arXiv:2602. 17750v2 Announce Type: replace-cross Abstract: A key problem of solid mechanics is the identification of the constitutive law of a material, that is, the relation between strain history and stress.
By Chenyi Ji, Kian P. Abdolazizi, Hagen Holthusen, Christian J. Cyron, Kevin Linka