arXiv:2606. 10889v1 Announce Type: cross Abstract: Early detection of neurodegeneration remains a critical clinical challenge.
Machine-generated by The Flow from the publisher's headline and feed description — not written or checked by a human. The full article lives at arXiv Machine Learning.
The paper presents a diagnostic framework for Alzheimer’s disease that uses the Large Brain Model (LaBraM), a foundation model pretrained on over 2,500 hours of EEG data, to generate high‑dimensional latent embeddings. These embeddings are fed into a non‑linear Random Forest classifier, achieving an ROC‑AUC of 89.36% ± 3.49%, PR AUC of 81.45% ± 4.43%, and Balanced Accuracy of 82.44% ± 4.34% in a subject‑independent 5‑fold cross‑validation setting, using only 8‑second EEG segments. Post‑hoc occlusion and neurophysiological alignment analyses confirm that the model captures clinically validated biomarkers such as occipital‑frontal Alpha and Theta rhythm degradation and correlates with cognitive performance and clinical severity.
arXiv:2608.28152v1 Announce Type: cross Abstract: Agitation fluctuates over short time horizons in people living with dementia, yet continuous physiological information for anticipating next-day risk...
SleepFM-2 is a foundation model trained on 282,511 polysomnography recordings, covering over two million hours of multimodal sleep physiology. It outperforms its predecessor in disease prediction, sleep scoring, and event detection, and its representation improves performance across diverse tasks—including wearable sensing, subjective sleep reports, and transfer to other EEG modalities. When combined with age, sex, and BMI, the model meets stringent discrimination criteria for 215 EHR phenotypes, adding reproducible information beyond demographics for 155 of them.
arXiv:2607. 28687v1 Announce Type: cross Abstract: As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs.
Pretrained EEG foundation models are increasingly proposed for clinical decoding, but their transfer across populations and robustness to negative controls remain unclear. We benchmark six models (LaBraM, EEGMamba, CBraMod, REVE, BENDR, and BIOT) on five clinical tasks across four datasets using frozen linear probes with leave-one-subject-out, subject-grouped, or explicitly identified recording-level splits.
Brain-PACE is a deep Siamese MRI framework that directly estimates the pace of structural brain ageing from paired T1‑weighted MRI scans, extending the LILAC model with spatial attention, soft label distribution learning, and a Cramér distance objective. In a study of participants with mild cognitive impairment, 42.6 % showed accelerated ageing, and faster Brain‑PACE scores correlated with greater functional and cognitive impairment as well as higher regional tau burden in key brain regions. The method improves probabilistic performance, reduces prediction bias, and provides predictive uncertainty, offering a complementary longitudinal imaging phenotype sensitive to early neurodegeneration.