Accurate ranking of antibody candidates according to their binding affinity is essential for therapeutic antibody discovery. However, existing methods treat affinity comparisons independently and ignore the contextual information encoded in other labeled comparisons, limiting their ability to capture antigen-specific binding landscapes.
arXiv:2607. 05846v1 Announce Type: cross Abstract: Accurate ranking of antibody candidates according to their binding affinity is essential for therapeutic antibody discovery.
By Zhiyuan Chen, Jing Hu, Junzhe Wang, Yueyang Huang, Xinyi Yang, Zhaoyang Wang, Feng Zhu
arXiv:2603. 10302v3 Announce Type: replace Abstract: A plethora of protein language models have been released in recent years.
By Calvin McCarter, Nick Bhattacharya, Sebastian W. Ober, Hunter Elliott
Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progress in single-chain protein modeling and generation, they often fall short in antigen-specific antibody design, where effective modeling requires explicit pairing between antibody and antigen, particularly at the epitope level.
arXiv:2607. 20057v1 Announce Type: cross Abstract: Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules.
By Xiaoliang Shi, Zichen Wang, Runze Ma, Zhongyue Zhang, Shuangjia Zheng
arXiv:2606. 07690v1 Announce Type: cross Abstract: Finetuning data selection requires balancing two competing goals: selecting examples that improve the downstream objective, and doing so without repeatedly finetuning models.
By Ning Wang, Zhengxin Zhang, Maosen Tang, Yitang Gao, Claire Cardie, Sainyam Galhotra