arXiv:2606. 08802v1 Announce Type: new Abstract: Standard flow and diffusion pre-training matches the distribution of available data (e.
By Riccardo De Santi, Bruce Lee, Cristian Perez Jensen, Kimon Protopapas, Sophia Tang, Cheng-Hao Liu, Pranam Chatterjee, Yisong Yue, Andreas Krause
arXiv:2601. 08379v2 Announce Type: replace-cross Abstract: Pre-trained diffusion models have emerged as powerful generative priors for both unconditional and conditional sample generation, yet their outputs often deviate from the characteristics of user-specific target data.
By Matina Mahdizadeh Sani, Nima Jamali, Mohammad Jalali, Farzan Farnia
Fenchel Tilt Flow Control (FTFC) is a new method for fine‑tuning pretrained generative models to arbitrary preference functions. It decouples utility optimization from model fitting by first learning reward and density‑ratio weights on pretrained samples, then freezing these weights to adjust a diffusion or flow model in a single importance‑weighted stage. The approach supports general f‑divergence penalties, achieves exact duality for concave utilities, and demonstrates up to 20× efficiency gains while outperforming baselines on image and molecule generation tasks.
By Maksim Bobrin, Maksim Zhdanov, Dmitry Dylov
The paper introduces Distribution‑Conditioned Transport (DCT), a framework that learns transport maps conditioned on embeddings of source and target distributions, allowing generalization to unseen distribution pairs. DCT supports semi‑supervised learning for distributional forecasting by leveraging distributions observed at only one condition. It is agnostic to the transport mechanism and is demonstrated on synthetic benchmarks and four biological applications, including batch effect transfer in single‑cell genomics and modeling T‑cell receptor sequence evolution.
By Nic Fishman, Gokul Gowri, Paolo L. B. Fischer, Marinka Zitnik, Omar Abudayyeh, Jonathan Gootenberg
arXiv:2608. 14293v1 Announce Type: cross Abstract: High-content microscopy enables systematic profiling of cellular responses to chemical perturbations, but the scale of the chemical space makes exhaustive phenotypic characterization experimentally infeasible.
By Gauthier Avit\'e, Maxime Sanchez-Renauld, Nicolas Bourriez, Auguste Genovesio
arXiv:2607. 17671v1 Announce Type: new Abstract: Large-scale single-cell perturbation atlases make it possible to ask an inverse question: given an observed transcriptional response, which annotated targets and compounds in a fixed library are most consistent with that response?
By Kseniia Vaniushkina, Jeongmin Lim, Jinyong Park