Spatial and Single-cell transcriptomics are transformative in deciphering cellular dynamics. As the fundamental paradigm for reconstructing cell developmental paths, trajectory inference (TI) is critical.
arXiv:2608. 14710v1 Announce Type: cross Abstract: Predicting spatial gene expression from hematoxylin and eosin (H\&E)-stained images offers a cost-effective alternative to spatial transcriptomics (ST).
By Ruochen Liu, Wei Lou
Scientific datasets are commonly organized as hierarchical repositories containing heterogeneous and interdependent files, making their inspection, integration, and analysis labor-intensive and reliant on domain expertise. Although large language model (LLM) agents have advanced substantially in planning, reasoning, and tool use, existing research has largely overlooked their ability to interact with real scientific data assets through executable environments.
arXiv:2606. 24235v1 Announce Type: new Abstract: Spatial proteomics enables single-cell-resolution characterization of protein expression within tissue architecture, playing a critical role in understanding tumor microenvironments and guiding precision medicine.
By Yucheng Yuan, Yuanfeng Ji, Zhongxiao Li, Ruijiang Li
arXiv:2607. 26722v1 Announce Type: cross Abstract: Harness plays a critical role in large language model agent performance, and building a high-performing harness requires substantial expert effort.
By Hanghui Guo, Weijie Shi, Zhangze Chen, Shengxiang Xu, Yishu Wang, Yimei Zhang, Wangze Ni, Jia Zhu, Shimin Di
arXiv:2601. 21800v4 Announce Type: replace Abstract: We introduce BioAgent Bench, an evaluation suite designed for measuring the performance and robustness of AI agents in common bioinformatics tasks.
By Dionizije Fa, Marko Culjak, Bruno Pandza, Mateo Cupic
Geographic Information System (GIS) professionals rely on multi-step spatial analysis workflows to support decision-making in urban planning, disaster response, and environmental monitoring. The process is tedious, time-consuming, and error-prone.
arXiv:2606. 31229v1 Announce Type: new Abstract: Ideation plays a pivotal role in scientific discovery.
By Keyu Zhao, Lingyan Kong, Fengli Xu, Yong Li
arXiv:2607. 16262v1 Announce Type: cross Abstract: The acceleration of automated scientific discovery has been fundamentally bottlenecked by the epistemic gap between the semantic reasoning of large language models (LLMs) and the deterministic physics of mammalian biology.
By Christopher Baker, Tianyu Ren, Karen Rafferty, Hui Wang, Simon McDade
arXiv:2606. 01640v1 Announce Type: new Abstract: Human mobility generation aims to synthesize realistic trip chains for target populations based on individual features.
By Junlin He, Yihong Tang, Tong Nie, Ao Qu, Yuebing Liang, Hamzeh Alizadeh, Bang Liu, Wei Ma, Lijun Sun
arXiv:2606. 06473v1 Announce Type: new Abstract: Large language model (LLM) agents are increasingly applied to long-horizon tasks such as scientific discovery and machine learning engineering (MLE), where sustained self-evolution becomes a key capability.
By Shangheng Du, Xiangchao Yan, Jinxin Shi, Zongsheng Cao, Shiyang Feng, Zichen Liang, Boyuan Sun, Tianshuo Peng, Yifan Zhou, Xin Li, Jie Zhou, Liang He, Bo Zhang, Lei Bai
Large Language Models (LLMs) have driven rapid progress in autonomous agents, yet standard evaluations remain confined to static task solving. An emerging frontier is harness evolution---the agent's capacity to autonomously optimize its own operating harness.