arXiv AI

A Research Prototype for Closed-Loop Generative Design of Customized Foot Orthoses via Semantic-Physics Alignment

arXiv:2607. 16631v1 Announce Type: new Abstract: Translating unstructured clinical prescriptions into patient-specific foot orthoses (FOs) is hindered by a semantic-physical misalignment: high-level clinical intent is not mapped deterministically onto the 3D geometric parameters of the orthosis, and existing design workflows remain dependent on manual expertise with no instantaneous biomechanical validation.

arXiv AI
Aug 26

Neurosymbolic Alignment for Physiologically-Safe Clinical Language Models

Neurosymbolic Alignment couples a 7B clinical language model with a graph‑based physiological world model to score candidate responses using homeostatic constraints, multi‑hop plausibility, and drug‑interaction penalties. This training‑time framework drives iterative on‑policy updates and achieves a 90.8% Clinical Safety Score on the CSB benchmark, outperforming ORPO, GPT‑4 (5‑shot), and a self‑correction pipeline. Ablation studies show that the HGNN scoring and iterative training are the key contributors to the safety gains.

By Abdulhady Abas Abdullah, Erik Cambria, Milena Zivkovic
arXiv Computer Vision
Aug 21

PhysSFI-Net: Physics-informed Geometric Learning of Skeletal and Facial Interactions for Orthognathic Surgical Outcome Prediction

arXiv:2601. 02088v3 Announce Type: replace Abstract: Orthognathic surgery repositions jaw bones to restore occlusion and enhance facial aesthetics.

By Jiahao Bao, Huazhen Liu, Yu Zhuang, Leran Tao, Xinyu Xu, Yongtao Shi, Mengjia Cheng, Yiming Wang, Congshuang Ku, Ting Zeng, Yilang Du, Siyi Chen, Shunyao Shen, Suncheng Xiang, Hongbo Yu
arXiv Computer Vision
Sep 17

Video-Based Markerless Motion Capture for Clinical and Rehabilitation Biomechanics: A PRISMA-ScR Scoping Review of Validated Architectures, Clinical Readiness, and Emerging Methods

This scoping review examined 117 studies on video-based markerless motion capture, most published from 2024 onward and focused on healthy adults walking in laboratories. The studies identified five main pipeline architectures, but most reported only raw joint angles without biomechanical refinement, achieving sagittal lower‑limb agreement of about 5–6°, which falls short of clinical acceptability. Validation of out‑of‑plane kinematics, kinetics, and performance in older or pathological populations was rare, and emerging computer‑vision techniques such as foundation‑model mesh recovery and differentiable inverse kinematics were largely absent from validated work.

By Florian Delaplace (LAMHESS, CHU), Elodie Piche (LAMHESS), Fr\'ed\'eric Chorin (IUF, LAMHESS), Raphael Zory (IUF, LAMHESS)
arXiv Machine Learning
Aug 5

A Physics-Flavored Transformer Network for Parametrizing Contraction Dynamics of Engineered Skeletal Muscle Tissues

arXiv:2608. 03927v1 Announce Type: new Abstract: Engineered Skeletal Muscle Tissues (ESMs) have become a key structure for biomedical disease modeling and pharmacological screening, yet their functional characterization often relies on simplistic metrics like peak force, discarding critical kinetic information.

By Mattias Luber, Timo Betz
arXiv Machine Learning
Jul 14

From Performance to Representational Adequacy: A Representational Bootstrap Framework for Adaptive Biological Systems

arXiv:2606. 01374v3 Announce Type: replace Abstract: Observable performance is commonly used to characterize biological systems, yet aggregated outputs may remain insufficient for uniquely resolving observational conditions, and richer multivariate representations may retain substantial ambiguity.

By Jacques Raynal, Pierre Slangen, Elsa Raynal, Jacques Margerit
arXiv AI
Aug 24

Anatomy-Informed Neural Networks: Encoding Anatomic Priors in Loss and Architecture, with an SE(3) Formulation of Guidewire-Induced Aortoiliac Deformation

The paper introduces Anatomy-Informed Neural Networks (AINN), which embed soft and hard anatomical priors into the loss function and network architecture to prevent anatomically impossible predictions. AINN is applied to a clinical scenario of aortoiliac deformation caused by a guidewire, modeling vessel and wire dynamics in SE(3) and training with a Wasserstein-2 loss from 2D angiograms. The study verifies the kinematics and loss against ground truth but does not yet train a network, outlining future work to apply the model to real CT data.

By David P. Stonko
arXiv AI
Aug 3

TAVI-TEC: An AI-Based Tool for Procedural Planning of Transcatheter Aortic Valve Implantation

arXiv:2607. 29243v1 Announce Type: cross Abstract: Computed tomography angiography (CTA) is crucial for preprocedural TAVI planning, providing the anatomical information required for prosthesis sizing and vascular access assessment.

By Alessandra Zerillo, Stefano Cannata, Diego Bellavia, Daniele Ciriello, Simone Manini, Salvatore Pasta, Caterina Gandolfo
arXiv AI
Aug 24

Generalizing Soft Tissue Deformation and Force Prediction Across Material Stiffness and Geometry

The paper presents a method for accurately simulating soft tissue deformation and predicting forces across varying material stiffnesses and geometries. It calibrates hyperelastic constitutive models in the SOFA Framework using gravity‑loaded silicone beams, then trains a softness‑conditioned equivariant graph neural network on the calibrated simulations. The resulting model achieves sub‑millimeter deformation accuracy with 0.010 s inference time, and demonstrates that force prediction quality depends on consistent upstream calibration.

By Madina Kojanazarova, Sidaty El Hadramy, Philippe C. Cattin