arXiv:2607. 02142v1 Announce Type: cross Abstract: Alzheimers disease (AD) is a brain disorder that develops slowly and mainly affects memory, thinking, language, and daily activities.
By Debopriya Ghosh
The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
By Yusuf Brima, Marcellin Atemkeng, Lakshmana Rao Namamula, Antoine Vacavant
arXiv:2607. 28687v1 Announce Type: cross Abstract: As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs.
By Mohammad Asif, Azizuddin Khan, Mohd Azam, Anurag Rajkumar Bombarde
arXiv:2606. 20037v1 Announce Type: new Abstract: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide.
By Loukas Ilias, Anthi-Maria Vozinaki, Christos Ntanos, Dimitris Askounis
The study evaluates whether inflammatory biomarkers can predict cognitive impairment in older Hispanic adults using interpretable machine learning on a small clinical dataset. A leakage‑safe Bernoulli/Categorical Naive Bayes model was trained on 165 participants from the Panama Aging Research Initiative, with continuous predictors discretized via supervised chi‑square and income treated categorically. The biomarker I‑309 (CCL1) emerged as the sole reliable incremental predictor, boosting ROC‑AUC from 0.630 to 0.740 and achieving statistically significant performance across repeated cross‑validation and random partitions.
By Antony Garcia, Gabrielle Britton, Alcibiades Villarreal, Diana Oviedo, Giselle Rangel, Xinming Huang
arXiv:2502. 03484v3 Announce Type: replace-cross Abstract: Dementia encompasses a group of syndromes that impair cognitive functions such as memory, reasoning, and the ability to perform daily activities.
By Marko Niemel\"a, Mikaela von Bonsdorff, Sami \"Ayr\"am\"o, Tommi K\"arkk\"ainen