Querying Counterfactuals on Tissue Graphs with Supervised Disentanglement
arXiv:2606. 08493v1 Announce Type: cross Abstract: \textit{Tissue graph counterfactuals} ask how a cell's expression would change under altered spatial neighbor contexts.
arXiv:2607. 13508v1 Announce Type: new Abstract: Quantifying directional influence between node populations is a fundamental problem in graph-based modeling, particularly in spatial biological systems where cell-cell interactions shape functional outcomes.
arXiv:2606. 08493v1 Announce Type: cross Abstract: \textit{Tissue graph counterfactuals} ask how a cell's expression would change under altered spatial neighbor contexts.
arXiv:2609.36046v1 Announce Type: cross Abstract: In spatial observational studies, treatment assignment and outcomes often exhibit spatial dependence patterns, and treatment effects may vary across...
arXiv:2607. 20896v1 Announce Type: new Abstract: Spatial transcriptomics assays remain costly and technically demanding, restricting transcriptome-wide profiling to specialist settings and preventing routine clinical deployment.
arXiv:2506. 11152v4 Announce Type: replace-cross Abstract: Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell level.
arXiv:2510. 08762v2 Announce Type: replace Abstract: Causal inference in spatial domains faces two intertwined challenges: (1) unmeasured spatial factors, such as weather, air pollution, or mobility, that confound treatment and outcome, and (2) interference from nearby treatments that violate standard no-interference assumptions.
SpaFactor is a lightweight framework that predicts spatial gene expression from hematoxylin and eosin images by fusing central spot visuals with multiscale neighborhood context. It uses a residual MLP to map tissue microenvironment to low‑dimensional latent gene programs, which are decoded into coordinated multi‑gene predictions. Across five public cohorts, SpaFactor outperforms existing methods, especially for spatially variable genes, and better recovers biologically organized spatial patterns.
arXiv:2504. 04739v3 Announce Type: replace Abstract: Understanding how social, demographic, environmental, and spatial factors jointly shape urban outcomes is essential for sustainable urban development and evidence-based policy.
arXiv:2509. 01916v2 Announce Type: replace Abstract: Causal disentanglement from soft interventions is identifiable under the assumptions of linear interventional faithfulness and availability of both observational and interventional data.
arXiv:2608. 06659v1 Announce Type: new Abstract: This paper shows that latent-space predictive pretraining can provide a scalable route to foundation models for spatial transcriptomics.
arXiv:2607. 14410v1 Announce Type: new Abstract: Spatially resolved omics studies increasingly combine transcriptomic and epigenomic assays, yet downstream analysis is often still performed using single-modality pipelines.
arXiv:2607. 19392v1 Announce Type: new Abstract: Arsenic contamination in groundwater presents a longstanding public health crisis in the United States, especially for households depending on private wells.
arXiv:2606. 05413v1 Announce Type: new Abstract: As urban environments continue to evolve rapidly, accurately modeling the dynamic behaviour of Points of Interest is essential for supporting data-driven urban planning and commercial decision-making.