arXiv Machine Learning

CDS: Counterfactual Directionality Score for Structured Interventions in Spatial Graphs

arXiv:2607. 13508v1 Announce Type: new Abstract: Quantifying directional influence between node populations is a fundamental problem in graph-based modeling, particularly in spatial biological systems where cell-cell interactions shape functional outcomes.

arXiv Machine Learning
Jul 24

HierarchicalDAEW: Domain-Aware Edge-Weighted Graph Convolution with Evidential Uncertainty for Multi-Section Spatial Gene Expression Prediction from H&E Histology

arXiv:2607. 20896v1 Announce Type: new Abstract: Spatial transcriptomics assays remain costly and technically demanding, restricting transcriptome-wide profiling to specialist settings and preventing routine clinical deployment.

By Kritanu Chattopadhyay, Soumya Chatterjee, Ondrej Krejcar, Debotosh Bhattacharjee
arXiv Machine Learning
Jun 5

HEIST: A Graph Foundation Model for Spatial Transcriptomics and Proteomics Data

arXiv:2506. 11152v4 Announce Type: replace-cross Abstract: Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell level.

By Hiren Madhu, Jo\~ao Felipe Rocha, Tinglin Huang, Siddharth Viswanath, Smita Krishnaswamy, Rex Ying
arXiv Machine Learning
Jun 30

Spatial Deconfounder: Interference-Aware Deconfounding for Spatial Causal Inference

arXiv:2510. 08762v2 Announce Type: replace Abstract: Causal inference in spatial domains faces two intertwined challenges: (1) unmeasured spatial factors, such as weather, air pollution, or mobility, that confound treatment and outcome, and (2) interference from nearby treatments that violate standard no-interference assumptions.

By Ayush Khot, Miruna Oprescu, Maresa Schr\"oder, Ai Kagawa, Xihaier Luo
arXiv Machine Learning
Sep 25

SpaFactor: Lightweight Spatial Context-Aware Gene Program Modeling for Histology-to-Transcriptomics Inference

SpaFactor is a lightweight framework that predicts spatial gene expression from hematoxylin and eosin images by fusing central spot visuals with multiscale neighborhood context. It uses a residual MLP to map tissue microenvironment to low‑dimensional latent gene programs, which are decoded into coordinated multi‑gene predictions. Across five public cohorts, SpaFactor outperforms existing methods, especially for spatially variable genes, and better recovers biologically organized spatial patterns.

By Shiting Ruan, Xitong Ling, Qiming He, Ziyou Yan, Huaitian Yuan, Tian Guan, Ying Xiao, Xu Guan, Yonghong He
arXiv Machine Learning
Jun 18

UST-GNN: A Unified Spatial--Topological Graph Neural Network Framework for Urban Analytics--Demonstrated through a Case Study on Urban Health Prediction

arXiv:2504. 04739v3 Announce Type: replace Abstract: Understanding how social, demographic, environmental, and spatial factors jointly shape urban outcomes is essential for sustainable urban development and evidence-based policy.

By Minwei Zhao, Sanja Scepanovic, Stephen Law, Ivica Obadic, Cai Wu, Daniele Quercia
arXiv Machine Learning
Jun 9

Causal Representation Learning from Network Data

arXiv:2509. 01916v2 Announce Type: replace Abstract: Causal disentanglement from soft interventions is identifiable under the assumptions of linear interventional faithfulness and availability of both observational and interventional data.

By Jifan Zhang, Michelle M. Li, Elena Zheleva