arXiv AI

From Black-Box to Clinical Insight: A Multi-Stage Explainable Framework for Speech-Based Cognitive Impairment Detection

arXiv:2606. 27973v1 Announce Type: cross Abstract: Speech-based cognitive impairment detection offers a noninvasive, accessible alternative to costly biomarker assays, yet transformer-based models remain clinically uninterpretable.

arXiv AI
Jun 3

ChatHealthAI: Aligning Electronic Health Record Representations with Large Language Models for Grounded Clinical Reasoning

arXiv:2606. 02802v1 Announce Type: new Abstract: Large language models (LLMs) exhibit strong natural-language reasoning abilities for clinical decision support, but struggle to effectively model structured longitudinal electronic health records (EHRs).

By Bo-Hong Wang, Baicheng Peng, Ruilin Wang, Jun Bai, Ziyang Song, Yue Li
arXiv AI
Jun 2

A Monosemantic Attribution Framework for Stable Interpretability in Clinical Neuroscience Transformer-Based Language Models

arXiv:2601. 17952v2 Announce Type: replace-cross Abstract: Interpretability remains a key challenge for deploying language models (LM) in clinical settings such as progression diagnosis of Alzheimer disease, where early and trustworthy predictions are essential.

By Michail Mamalakis, Tiago Azevedo, Cristian Cosentino, Chiara D'Ercoli, Subati Abulikemu, Zhongtian Sun, Richard Bethlehem, Pietro Lio
arXiv AI
Jun 30

Primary ICD Category Prediction using LLM-based Probing

arXiv:2606. 28798v1 Announce Type: new Abstract: Objective: ICD codes are central to reimbursement, research, and population health surveillance, yet automated coding systems often struggle to integrate diagnostic signals from both clinical narratives and structured electronic health record (EHR) variables.

By Chengyuan Liu, Xinyue Zhang, Yao Li, Guanting Chen
arXiv AI
1d ago

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

arXiv:2505. 14107v5 Announce Type: replace-cross Abstract: The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios.

By Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang
arXiv AI
Jul 8

X-FEMR: A Token-level Explainable Approach for Electronic Health Records Foundation Models using Transformer-based Models

arXiv:2607. 06163v1 Announce Type: cross Abstract: Foundation Models for Electronic Health Records (FEMRs) are pretrained on large-scale structured patient data, enabling them to convert longitudinal patient trajectories into generalizable representations for diverse clinical prediction tasks.

By Jie Huang, Pengfei Yin, Zihan Xu, Daniel Capurro, Mike Conway, Ting Dang
arXiv AI
Jul 29

Evaluating Multi-Turn Multimodal Diagnostic Reasoning on Challenging Real-World Clinical Cases

arXiv:2607. 25933v1 Announce Type: cross Abstract: Clinical diagnostic evaluation should not only assess whether models can provide correct diagnoses, but also reflect the realities of clinical practice, including progressive disclosure of multimodal information, dynamic updating of diagnostic hypotheses, and continuous refinement of clinical reasoning.

By Rui Yang, Weihao Xuan, Yi Lin, Zhuhan Bao, Jonathan Chong Kai Liew, Matthew Yu Heng Wong, Nicol\'as Lescano, Nikita R. Paripati, Emily Ling-Lin Pai, Jiarui Liu, Heli Qi, Heng-Jui Chang, Benny Kai Guo Loo, Huitao Li, Kunyu Yu, Yufan Wang, Chuan Hong, Shijian Lu, Douglas Teodoro, Naoto Yokoya, Ross Koppel, Mona Diab, Hua Xu, David W. Bates, Nan Liu, Yifan Peng
arXiv AI
Jun 17

AIPatient Arena: EHR-grounded evaluation of large language models in end-to-end clinical consultation workflows

arXiv:2606. 17474v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly considered for use in clinical consultation tasks, yet most medical evaluations remain static, single-turn, or narrowly outcome-based, limiting their ability to reflect the sequential, uncertain, and interactive nature of real-world care.

By Jiahui Niu, Huizi Yu, Wenkong Wang, Guangxin Dai, Jingxian He, Xiang Li, Zhiying Liang, Xinxin Lin, Kent CY So, Bryan YP Yan, Yun Kwok Wing, Yanqiu Xing, Xin Ma, Lizhou Fan
arXiv Machine Learning
Aug 7

Clinician input steers AI toward accurate and harmful recommendations

arXiv:2603. 14158v2 Announce Type: replace-cross Abstract: Large language models (LLMs) are entering clinical workflows, yet evaluations rarely assess how clinician reasoning shapes model behavior during clinical interactions.

By Ivan Lopez, Selin S. Everett, Bryan J. Bunning, April S. Liang, Dong Han Yao, Shivam C. Vedak, Kameron C. Black, Sophie Ostmeier, Stephen P. Ma, Emily Alsentzer, Jonathan H. Chen, Akshay S. Chaudhari, Eric Horvitz